Technology Process of (2R)-N-[(4Z)-8-benzyloxyocten-1-oyl]bornane-10,2-sultam
There total 6 articles about (2R)-N-[(4Z)-8-benzyloxyocten-1-oyl]bornane-10,2-sultam which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2R)-bornane-10,2-sultam;
With
n-butyllithium;
In
hexane; toluene;
at 20 ℃;
for 2h;
(4Z)-8-(benzyloxy)-4-octenoyl chloride;
In
hexane; toluene;
at 20 ℃;
DOI:10.1039/b406280a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.33 h / 0 °C
1.2: 65 percent / tetrahydrofuran / 1.5 h / -78 °C
2.1: 97 percent / aq. NaOH / tetrahydrofuran / 20 °C
3.1: oxalyl chloride / 3 h / 20 °C
4.1: n-BuLi / hexane; toluene / 2 h / 20 °C
4.2: 79 percent / hexane; toluene / 20 °C
With
sodium hydroxide; n-butyllithium; oxalyl dichloride; sodium hexamethyldisilazane;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1039/b406280a
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 99 percent / DMSO; oxalyl chloride; Et3N / CH2Cl2 / 2 h / -78 °C
2.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.33 h / 0 °C
2.2: 65 percent / tetrahydrofuran / 1.5 h / -78 °C
3.1: 97 percent / aq. NaOH / tetrahydrofuran / 20 °C
4.1: oxalyl chloride / 3 h / 20 °C
5.1: n-BuLi / hexane; toluene / 2 h / 20 °C
5.2: 79 percent / hexane; toluene / 20 °C
With
sodium hydroxide; n-butyllithium; oxalyl dichloride; sodium hexamethyldisilazane; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane; toluene;
1.1: Swern oxidation;
DOI:10.1039/b406280a
