8-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one

Base Information

• Chemical Name: 8-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one
• CAS No.: 932707-95-4
• Molecular Formula: C₁₈H₁₆ClNO₄S
• Molecular Weight: 377.848

Synonyms:8-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one

Chemical Property of 8-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one

Chemical Property:

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Technology Process of 8-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one

There total 1 articles about 8-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2-chloro-5-hydroxyphenyl)-2-(4-methanesulfonylbenzyl)-3-oxo-butyramide (932707-94-3) → 8-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one (932707-95-4)

Guidance literature:

With methanesulfonic acid; at 100 ℃; for 0.166667h;

Reference yield:

8-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one (932707-95-4) + phenyl trifluoromethanesulfonamide (456-64-4) → trifluoromethanesulfonic acid 8-chloro-3-(4-methanesulfonylbenzyl)-4-methyl-2-oxo-1,2-dihydroquinolin-5-yl ester (932708-04-8)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 130 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

8-chloro-5-hydroxy-3-(4-methanesulfonylbenzyl)-4-methyl-1H-quinolin-2-one (932707-95-4) + bromoacetic acid methyl ester (96-32-2) → [8-chloro-3-(4-methanesulfonylbenzyl)-4-methyl-2-oxo-1,2-dihydroquinoIin-5-yloxy]acetic acid methyl ester (932707-96-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

upstream raw materials:

N-(2-chloro-5-hydroxyphenyl)-2-(4-methanesulfonylbenzyl)-3-oxo-butyramide

Downstream raw materials:

trifluoromethanesulfonic acid 8-chloro-3-(4-methanesulfonylbenzyl)-4-methyl-2-oxo-1,2-dihydroquinolin-5-yl ester

[8-chloro-3-(4-methanesulfonylbenzyl)-4-methyl-2-oxo-1,2-dihydroquinoIin-5-yloxy]acetic acid methyl ester

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