2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfanylethanol

Base Information

• Chemical Name: 2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfanylethanol
• CAS No.: 899820-39-4
• Molecular Formula: C₁₆H₁₆F₂O₃S
• Molecular Weight: 326.364
• Mol file: 899820-39-4.mol

Synonyms:2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfanylethanol

Chemical Property of 2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfanylethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfanylethanol

There total 1 articles about 2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfanylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

3,4-dimethoxy-benzaldehyde (120-14-9) + phenyl (trimethylsilyl)difluoromethyl sulfide (536975-49-2) → 2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfanylethanol (899820-39-4) + 2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfanyl-1-trimethoxysiloxyethane

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.tet.2006.04.015

Reference yield: 70.0%

2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfanylethanol (899820-39-4) → 2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfinylethanol (899820-62-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.tet.2006.04.015

Reference yield:

2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfanylethanol (899820-39-4) → 1,1-difluoro-2-(3,4-dimethoxyphenyl)ethene (131581-41-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / m-chloroperbenzoic acid / tetrahydrofuran / -78 - 20 °C

2: 71 percent / 170 - 200 °C / 0.05 Torr

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran;

DOI:10.1016/j.tet.2006.04.015

upstream raw materials:

3,4-dimethoxy-benzaldehyde

phenyl (trimethylsilyl)difluoromethyl sulfide

Downstream raw materials:

2,2-difluoro-1-(3,4-dimethoxyphenyl)-2-phenylsulfinylethanol

1,1-difluoro-2-(3,4-dimethoxyphenyl)ethene