methyl 2-chloro-3-{4-[2-(N,N-diisopropylamino)ethyloxy]phenyl}propionate

Base Information

Chemical Name:methyl 2-chloro-3-{4-[2-(N,N-diisopropylamino)ethyloxy]phenyl}propionate
CAS No.:74773-33-4
Molecular Formula:C₁₈H₂₈ClNO₃
Molecular Weight:341.878
Hs Code.:

Synonyms:methyl 2-chloro-3-{4-[2-(N,N-diisopropylamino)ethyloxy]phenyl}propionate

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Chemical Property of methyl 2-chloro-3-{4-[2-(N,N-diisopropylamino)ethyloxy]phenyl}propionate

Chemical Property:

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Technology Process of methyl 2-chloro-3-{4-[2-(N,N-diisopropylamino)ethyloxy]phenyl}propionate

There total 4 articles about methyl 2-chloro-3-{4-[2-(N,N-diisopropylamino)ethyloxy]phenyl}propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-00-5
4-chlorobenzonitrile

: 74773-33-4
methyl 2-chloro-3-{4-[2-(N,N-diisopropylamino)ethyloxy]phenyl}propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 67.2 percent / NaH / dimethylsulfoxide / 0.5 h / 70 °C

2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

3: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C

With copper(I) oxide; hydrogenchloride; hydrogen; sodium hydride; sodium nitrite; palladium on activated charcoal; In methanol; dimethyl sulfoxide;
DOI:10.1248/cpb.30.3580

Reference yield:

: 96-80-0
2-(diisopropylamino)ethanol

: 74773-33-4
methyl 2-chloro-3-{4-[2-(N,N-diisopropylamino)ethyloxy]phenyl}propionate

Guidance literature:: Multi-step reaction with 3 steps

1: 67.2 percent / NaH / dimethylsulfoxide / 0.5 h / 70 °C

2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

3: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C

With copper(I) oxide; hydrogenchloride; hydrogen; sodium hydride; sodium nitrite; palladium on activated charcoal; In methanol; dimethyl sulfoxide;
DOI:10.1248/cpb.30.3580

Reference yield:

: 85002-94-4
Diisopropyl-[2-(4-nitro-phenoxy)-ethyl]-amine

: 74773-33-4
methyl 2-chloro-3-{4-[2-(N,N-diisopropylamino)ethyloxy]phenyl}propionate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

2: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C

With copper(I) oxide; hydrogenchloride; hydrogen; sodium nitrite; palladium on activated charcoal; In methanol;
DOI:10.1248/cpb.30.3580