((S)-2-{3-[4-(2-Iodo-ethyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:((S)-2-{3-[4-(2-Iodo-ethyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester
CAS No.:184872-84-2
Molecular Formula:C₂₈H₃₆IN₃O₄
Molecular Weight:605.516
Hs Code.:

Synonyms:((S)-2-{3-[4-(2-Iodo-ethyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

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Chemical Property of ((S)-2-{3-[4-(2-Iodo-ethyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ((S)-2-{3-[4-(2-Iodo-ethyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

There total 9 articles about ((S)-2-{3-[4-(2-Iodo-ethyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 184872-83-1
((S)-2-{3-[4-(2-Chloro-ethyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

: 184872-84-2
((S)-2-{3-[4-(2-Iodo-ethyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: With sodium iodide; In acetone; for 18h; Heating;
DOI:10.1016/0040-4020(96)00872-1

Reference yield:

: 41175-39-7
4-hydroxy-2-phenyl-butanenitrile

: 184872-84-2
((S)-2-{3-[4-(2-Iodo-ethyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / pyridine / CHCl₃ / Ambient temperature

2: 97 percent / H₂, CHCl₃ / PtO₂ / 3 h / 76 Torr / Ambient temperature

3: 57 percent / KF/Celite / acetonitrile / 48 h / 40 °C

4: 95 percent / Et₃N / CHCl₃ / 14 h

5: 58 percent / POCl₃ / 155 - 175 °C

6: N₂H₄*H₂O / ethanol / 0.5 h / 60 °C

7: 2-chloro-1-methylpyridinium iodide, Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

8: 98 percent / NaI / acetone / 18 h / Heating

With pyridine; potassium fluoride; chloroform; Celite; 2-chloro-1-methyl-pyridinium iodide; hydrogen; hydrazine hydrate; triethylamine; sodium iodide; trichlorophosphate; platinum(IV) oxide; In ethanol; dichloromethane; chloroform; acetone; acetonitrile;
DOI:10.1016/0040-4020(96)00872-1

Reference yield:

: 57371-15-0
3-cyano-3-phenylpropyl acetate

: 184872-84-2
((S)-2-{3-[4-(2-Iodo-ethyl)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propylcarbamoyl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / H₂, CHCl₃ / PtO₂ / 3 h / 76 Torr / Ambient temperature

2: 57 percent / KF/Celite / acetonitrile / 48 h / 40 °C

3: 95 percent / Et₃N / CHCl₃ / 14 h

4: 58 percent / POCl₃ / 155 - 175 °C

5: N₂H₄*H₂O / ethanol / 0.5 h / 60 °C

6: 2-chloro-1-methylpyridinium iodide, Et₃N / CH₂Cl₂ / 3 h / Ambient temperature

7: 98 percent / NaI / acetone / 18 h / Heating

With potassium fluoride; chloroform; Celite; 2-chloro-1-methyl-pyridinium iodide; hydrogen; hydrazine hydrate; triethylamine; sodium iodide; trichlorophosphate; platinum(IV) oxide; In ethanol; dichloromethane; chloroform; acetone; acetonitrile;
DOI:10.1016/0040-4020(96)00872-1