methyl 3-oxo-3-(p-tolyl)-2-(triphenylphosphoranylidene)propanoate

Base Information

• Chemical Name: methyl 3-oxo-3-(p-tolyl)-2-(triphenylphosphoranylidene)propanoate
• CAS No.: 96372-85-9
• Molecular Formula: C₂₉H₂₅O₃P
• Molecular Weight: 452.489
• Mol file: 96372-85-9.mol

Synonyms:methyl 3-oxo-3-(p-tolyl)-2-(triphenylphosphoranylidene)propanoate

Chemical Property of methyl 3-oxo-3-(p-tolyl)-2-(triphenylphosphoranylidene)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 3-oxo-3-(p-tolyl)-2-(triphenylphosphoranylidene)propanoate

There total 2 articles about methyl 3-oxo-3-(p-tolyl)-2-(triphenylphosphoranylidene)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

carbon monoxide (201230-82-2) + 4-tolyl iodide (624-31-7) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → methyl 3-oxo-3-(p-tolyl)-2-(triphenylphosphoranylidene)propanoate (96372-85-9)

Guidance literature:

With potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium dichloride; In 1,4-dioxane; at 100 ℃; for 24h; under 760.051 Torr; Autoclave;

DOI:10.1021/acs.orglett.6b02278

Reference yield:

4-methyl-benzoyl chloride (874-60-2) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → methyl 3-oxo-3-(p-tolyl)-2-(triphenylphosphoranylidene)propanoate (96372-85-9)

Guidance literature:

In benzene;

Reference yield:

methyl 3-oxo-3-(p-tolyl)-2-(triphenylphosphoranylidene)propanoate (96372-85-9) → 5-Methyl-2-(triphenyl-λ5-phosphanylidene)-indan-1,3-dione (96276-92-5)

Guidance literature:

With phosphorus pentachloride; In chloroform;

upstream raw materials:

4-methyl-benzoyl chloride

methyl (triphenylphosphoranylidene)acetate

carbon monoxide

4-tolyl iodide

Downstream raw materials:

3-(4-methylphenyl)prop-2-ynoic acid

5-Methyl-2-(triphenyl-λ⁵-phosphanylidene)-indan-1,3-dione