(2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid oxiranylmethyl-amide

Base Information

Chemical Name:(2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid oxiranylmethyl-amide
CAS No.:616894-67-8
Molecular Formula:C₂₅H₂₉N₃O₉
Molecular Weight:515.52
Hs Code.:

(2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid oxiranylmethyl-amide

Synonyms:(2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid oxiranylmethyl-amide

Suppliers and Price of (2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid oxiranylmethyl-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid oxiranylmethyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid oxiranylmethyl-amide

There total 4 articles about (2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid oxiranylmethyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 616894-66-7
(2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid allylamide

: 616894-67-8
(2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid oxiranylmethyl-amide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/ol0355074

Reference yield:

: 121845-98-5
(3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde

: 616894-67-8
(2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid oxiranylmethyl-amide

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / aq. NaOH / CH₂Cl₂ / 2.5 h

2: 76 percent / DDQ / benzene / 24 h / Heating

3: 59 percent / tetrahydrofuran / 12 h / 50 °C

4: m-CPBA / CH₂Cl₂ / 2 h / 0 °C

With sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/ol0355074

Reference yield:

: 616894-53-2
1-{(3aR,4R,6R,6aR)-6-[(2S,3R)-3-(Indole-1-carbonyl)-oxiranyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-3-(4-methoxy-benzyl)-1H-pyrimidine-2,4-dione

: 616894-67-8
(2R,3S)-3-{(3aR,4R,6R,6aR)-6-[3-(4-Methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-oxirane-2-carboxylic acid oxiranylmethyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 59 percent / tetrahydrofuran / 12 h / 50 °C

2: m-CPBA / CH₂Cl₂ / 2 h / 0 °C

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol0355074