[3-(4-tert-butoxycarbonylamino-butylcarbamoyl)-5-(dimethoxy-phosphorylmethyl)-benzyl]-phosphonic acid dimethyl ester

Base Information

Chemical Name:[3-(4-tert-butoxycarbonylamino-butylcarbamoyl)-5-(dimethoxy-phosphorylmethyl)-benzyl]-phosphonic acid dimethyl ester
CAS No.:223449-74-9
Molecular Formula:C₂₂H₃₈N₂O₉P₂
Molecular Weight:536.499
Hs Code.:

[3-(4-<i>tert</i>-butoxycarbonylamino-butylcarbamoyl)-5-(dimethoxy-phosphorylmethyl)-benzyl]-phosphonic acid dimethyl ester

Synonyms:[3-(4-tert-butoxycarbonylamino-butylcarbamoyl)-5-(dimethoxy-phosphorylmethyl)-benzyl]-phosphonic acid dimethyl ester

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Chemical Property of [3-(4-tert-butoxycarbonylamino-butylcarbamoyl)-5-(dimethoxy-phosphorylmethyl)-benzyl]-phosphonic acid dimethyl ester

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Technology Process of [3-(4-tert-butoxycarbonylamino-butylcarbamoyl)-5-(dimethoxy-phosphorylmethyl)-benzyl]-phosphonic acid dimethyl ester

There total 5 articles about [3-(4-tert-butoxycarbonylamino-butylcarbamoyl)-5-(dimethoxy-phosphorylmethyl)-benzyl]-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 68076-36-8
1-amino-4-[(tert-butyloxycarbonyl)amino]butane

: 223449-19-2
5-carboxy-m-xylylenebisphosphonic acid tetramethyl ester

: 223449-74-9
[3-(4-tert-butoxycarbonylamino-butylcarbamoyl)-5-(dimethoxy-phosphorylmethyl)-benzyl]-phosphonic acid dimethyl ester

Guidance literature:: With 4-methyl-morpholine; dmap; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1016/S0040-4020(99)00062-9

Reference yield:

: 94111-75-8
3,5-bis(bromomethyl)benzoic acid

: 223449-74-9
[3-(4-tert-butoxycarbonylamino-butylcarbamoyl)-5-(dimethoxy-phosphorylmethyl)-benzyl]-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 16 h / Heating

2: LiOH / methanol; H₂O / 7 h / 0 °C

3: 38 percent / BOP, DMAP, HOBt*H₂O, NMM / dimethylformamide / 24 h / Ambient temperature

With 4-methyl-morpholine; dmap; lithium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(99)00062-9

Reference yield:

: 38588-64-6
3,5-bis(methoxycarbonyl)benzoic acid

: 223449-74-9
[3-(4-tert-butoxycarbonylamino-butylcarbamoyl)-5-(dimethoxy-phosphorylmethyl)-benzyl]-phosphonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 49 percent / 1 M lithium triethylborohydride / tetrahydrofuran

2: 90 percent / PBr₃

3: 16 h / Heating

4: LiOH / methanol; H₂O / 7 h / 0 °C

5: 38 percent / BOP, DMAP, HOBt*H₂O, NMM / dimethylformamide / 24 h / Ambient temperature

With 4-methyl-morpholine; dmap; lithium hydroxide; phosphorus tribromide; lithium triethylborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(99)00062-9