2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methoxy-3-methylquinolin-5-amine

Base Information

Chemical Name:2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methoxy-3-methylquinolin-5-amine
CAS No.:1415353-93-3
Molecular Formula:C₂₅H₃₂N₂O₄
Molecular Weight:424.54
Hs Code.:

Synonyms:2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methoxy-3-methylquinolin-5-amine

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Chemical Property of 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methoxy-3-methylquinolin-5-amine

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Technology Process of 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methoxy-3-methylquinolin-5-amine

There total 8 articles about 2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methoxy-3-methylquinolin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1415353-86-4
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-iodo-3-methylquinolin-5-amine

: 124-41-4
sodium methylate

: 1415353-93-3
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methoxy-3-methylquinolin-5-amine

Guidance literature:: With copper(I) bromide; In methanol; ethyl acetate; for 3h; Reflux;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

: 1415354-00-5
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-8-methoxy-3-methylquinolin-5-amine

: 75-07-0,9002-91-9
acetaldehyde

: 1415353-93-3
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methoxy-3-methylquinolin-5-amine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; methanol; at 20 ℃; for 14.5h;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028

Reference yield:

: 132118-31-1
2-chloro-8-methoxy-3-methylquinoline

: 1415353-93-3
2-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-N,N-diethyl-8-methoxy-3-methylquinolin-5-amine

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 3.5 h / -10 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,4-dioxane / 1.5 h / Reflux

3: ammonium chloride; iron / water; ethanol / 1 h / Reflux

4: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran; methanol / 14.5 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; nitric acid; sodium tris(acetoxy)borohydride; iron; potassium carbonate; ammonium chloride; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2012.09.028 DOI:10.1016/j.bmc.2012.09.028