(S)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepine-1-carboxylate

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Chemical Name:(S)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepine-1-carboxylate
CAS No.:1413176-84-7
Molecular Formula:C₂₅H₄₀N₂O₅Si
Molecular Weight:476.688
Hs Code.:

Synonyms:(S)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepine-1-carboxylate

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Chemical Property of (S)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepine-1-carboxylate

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Technology Process of (S)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepine-1-carboxylate

There total 7 articles about (S)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.1%

: 1413176-70-1
tert-butyl (S)-allyl((1-(tert-butyldimethylsilyloxy)but-3-en-2-yl)(4-methoxybenzyl)carbamoyl)carbamate

: 1413176-84-7
(S)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepine-1-carboxylate

Guidance literature:: tert-butyl (S)-allyl((1-(tert-butyldimethylsilyloxy)but-3-en-2-yl)(4-methoxybenzyl)carbamoyl)carbamate; With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 12h; Inert atmosphere;

In dichloromethane; for 4h;
DOI:10.1039/c2cc35484e

Reference yield:

: 1413176-67-6
(S)-1-(tert-butyldimethylsilyloxy)-N-(4-methoxybenzyl)but-3-en-2-amine

: 1413176-84-7
(S)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 20 °C / Cooling with ice

2.1: dmap; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: Inert atmosphere; Reflux

3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 12 h / Inert atmosphere

3.2: air / 4 h

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2cc35484e

Reference yield:

: C₂₁H₃₄N₂O₃Si

: 1413176-84-7
(S)-tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-3-(4-methoxybenzyl)-2-oxo-2,3,4,7-tetrahydro-1H-1,3-diazepine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

1.2: Inert atmosphere; Reflux

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 12 h / Inert atmosphere

2.2: air / 4 h

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2cc35484e