methyl (R)-3-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzylamino)propanoate

Base Information

Chemical Name:methyl (R)-3-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzylamino)propanoate
CAS No.:1413176-63-2
Molecular Formula:C₁₈H₃₁NO₄Si
Molecular Weight:353.534
Hs Code.:

Synonyms:methyl (R)-3-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzylamino)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (R)-3-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzylamino)propanoate

Chemical Property:

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Technology Process of methyl (R)-3-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzylamino)propanoate

There total 1 articles about methyl (R)-3-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzylamino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.7%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 153046-00-5
(R)-methyl 3-hydroxy-2-(4-methoxybenzylamino)propanoate

: 1413176-63-2
methyl (R)-3-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzylamino)propanoate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1039/c2cc35484e

Reference yield:

: 1413176-63-2
methyl (R)-3-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzylamino)propanoate

: 1538-75-6
2,2-dimethylpropanoic anhydride

: C₁₇H₂₉NO₃Si

Guidance literature:: methyl (R)-3-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzylamino)propanoate; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

2,2-dimethylpropanoic anhydride; In tetrahydrofuran; at 0 ℃; Inert atmosphere; Reflux;

With diisobutylaluminium hydride; In water; toluene; at -78 ℃;
DOI:10.1039/c2cc35484e

Reference yield:

: 1413176-63-2
methyl (R)-3-(tert-butyldimethylsilyloxy)-2-(4-methoxybenzylamino)propanoate

: 1413176-65-4
(S)-tert-butyl 1-(tert-butyldimethylsilyloxy)but-3-en-2-yl(4-methoxybenzyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

1.2: 0 °C / Inert atmosphere; Reflux

1.3: -78 °C

2.1: Tabbe’s reagent / tetrahydrofuran; toluene / 2 h / 20 °C

With triethylamine; In tetrahydrofuran; toluene;
DOI:10.1039/c2cc35484e