1,3-Bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxo-5-((trifluoromethanesulfonyl)oxy)pyrrolo<2,3-d>pyrimidine

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Chemical Name:1,3-Bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxo-5-((trifluoromethanesulfonyl)oxy)pyrrolo<2,3-d>pyrimidine
CAS No.:145744-99-6
Molecular Formula:C₃₂H₃₀F₃N₃O₉S
Molecular Weight:689.666
Hs Code.:

Synonyms:1,3-Bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxo-5-((trifluoromethanesulfonyl)oxy)pyrrolo<2,3-d>pyrimidine

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Chemical Property of 1,3-Bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxo-5-((trifluoromethanesulfonyl)oxy)pyrrolo<2,3-d>pyrimidine

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Technology Process of 1,3-Bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxo-5-((trifluoromethanesulfonyl)oxy)pyrrolo<2,3-d>pyrimidine

There total 7 articles about 1,3-Bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxo-5-((trifluoromethanesulfonyl)oxy)pyrrolo<2,3-d>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 145744-98-5
1,3-Bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxo-5-hydroxypyrrolo<2,3-d>pyrimidine

: 145744-99-6
1,3-Bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxo-5-((trifluoromethanesulfonyl)oxy)pyrrolo<2,3-d>pyrimidine

Guidance literature:: With 2,4,6-trimethyl-pyridine; In dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1021/jo00054a024

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 145744-99-6
1,3-Bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxo-5-((trifluoromethanesulfonyl)oxy)pyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 1) LiH / 1) DMF, 0 deg C, 30 min., 2) r.t., 5 h

2: 1) NaOH, 2) Na₂CO₃ / 1) H₂O, reflux, 1 h, 2) EtOH, reflux, 13.5 h

3: 1) 70 deg C, 2 h, 2) reflux, 45 min.

4: 84.6 percent / Na₂CO₃*H₂O / methanol / 0.08 h / Heating

5: 99 percent / 2,4,6-collidine / CH₂Cl₂ / 0.25 h / -78 °C

With 2,4,6-trimethyl-pyridine; sodium hydroxide; lithium hydride; sodium carbonate; In methanol; dichloromethane;
DOI:10.1021/jo00054a024

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 145744-99-6
1,3-Bis((benzyloxy)methyl)-7-(2,4-dimethoxybenzyl)-2,4-dioxo-5-((trifluoromethanesulfonyl)oxy)pyrrolo<2,3-d>pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: benzene / Heating

2: 1) NaOH, 2) Na₂CO₃ / 1) H₂O, reflux, 1 h, 2) EtOH, reflux, 13.5 h

3: 1) 70 deg C, 2 h, 2) reflux, 45 min.

4: 84.6 percent / Na₂CO₃*H₂O / methanol / 0.08 h / Heating

5: 99 percent / 2,4,6-collidine / CH₂Cl₂ / 0.25 h / -78 °C

With 2,4,6-trimethyl-pyridine; sodium hydroxide; sodium carbonate; In methanol; dichloromethane; benzene;
DOI:10.1021/jo00054a024