{(2R,3S)-3-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxiranyl}-methanol

Base Information

Chemical Name:{(2R,3S)-3-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxiranyl}-methanol
CAS No.:190896-37-8
Molecular Formula:C₂₀H₃₄O₄Si
Molecular Weight:366.573
Hs Code.:

Synonyms:{(2R,3S)-3-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxiranyl}-methanol

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Chemical Property of {(2R,3S)-3-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxiranyl}-methanol

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Technology Process of {(2R,3S)-3-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxiranyl}-methanol

There total 6 articles about {(2R,3S)-3-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxiranyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 190896-55-0
(Z)-3-Benzyloxymethyl-4-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-but-2-en-1-ol

: 190896-37-8
{(2R,3S)-3-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxiranyl}-methanol

Guidance literature:: With titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2S,3S)-tartrate; In 2,2,4-trimethylpentane; dichloromethane; at -20 ℃; for 4h;
DOI:10.1016/S0040-4020(97)00453-5

Reference yield:

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 190896-37-8
{(2R,3S)-3-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxiranyl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / CF₃SO₃H / hexane; CH₂Cl₂ / 0.42 h / Heating

2: 95 percent / diisobutylaluminum hydride / diethyl ether; hexane / 1.) -78 deg C, 25 min, 2.) 0 deg C, 2 h, then 25 deg C, 2 h

3: 7.46 g / n-BuLi / tetrahydrofuran; hexane / 5 h / Ambient temperature

4: 86 percent / D-(-)-diethyl tartrate, Ti(O-i-Pr)4, TBHP / CH₂Cl₂; 2,2,4-trimethyl-pentane / 4 h / -20 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; diethyl (2S,3S)-tartrate; trifluorormethanesulfonic acid; diisobutylaluminium hydride; In tetrahydrofuran; 2,2,4-trimethylpentane; diethyl ether; hexane; dichloromethane;
DOI:10.1016/S0040-4020(97)00453-5

Reference yield:

: 80904-75-2
4-hydroxymethyl-5H-furan-2-one

: 190896-37-8
{(2R,3S)-3-Benzyloxymethyl-3-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxymethyl]-oxiranyl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / CF₃SO₃H / hexane; CH₂Cl₂ / 0.42 h / Heating

2: 95 percent / diisobutylaluminum hydride / diethyl ether; hexane / 1.) -78 deg C, 25 min, 2.) 0 deg C, 2 h, then 25 deg C, 2 h

3: 7.46 g / n-BuLi / tetrahydrofuran; hexane / 5 h / Ambient temperature

4: 86 percent / D-(-)-diethyl tartrate, Ti(O-i-Pr)4, TBHP / CH₂Cl₂; 2,2,4-trimethyl-pentane / 4 h / -20 °C

With titanium(IV) isopropylate; tert.-butylhydroperoxide; n-butyllithium; diethyl (2S,3S)-tartrate; trifluorormethanesulfonic acid; diisobutylaluminium hydride; In tetrahydrofuran; 2,2,4-trimethylpentane; diethyl ether; hexane; dichloromethane;
DOI:10.1016/S0040-4020(97)00453-5