<3-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy>acetyl-L-(S-p-methoxybenzyl)cysteinyl-D-valine benzhydryl ester

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Chemical Name:<3-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy>acetyl-L-(S-p-methoxybenzyl)cysteinyl-D-valine benzhydryl ester
CAS No.:113787-86-3
Molecular Formula:C₃₉H₃₉F₃N₄O₆S
Molecular Weight:748.823
Hs Code.:

Synonyms:<3-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy>acetyl-L-(S-p-methoxybenzyl)cysteinyl-D-valine benzhydryl ester

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Chemical Property of <3-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy>acetyl-L-(S-p-methoxybenzyl)cysteinyl-D-valine benzhydryl ester

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Technology Process of <3-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy>acetyl-L-(S-p-methoxybenzyl)cysteinyl-D-valine benzhydryl ester

There total 9 articles about <3-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy>acetyl-L-(S-p-methoxybenzyl)cysteinyl-D-valine benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 113787-85-2
3-(3-hydroxyhenyl)-3-(trifluoromethyl)-3H-diazirine

: 113787-79-4
iodoacetyl-L-(S-p-methoxybenzyl)cysteinyl-D-valine benzhydryl ester

: 113787-86-3
<3-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy>acetyl-L-(S-p-methoxybenzyl)cysteinyl-D-valine benzhydryl ester

Guidance literature:: With potassium carbonate; In acetone; in the dark;
DOI:10.1016/S0040-4020(01)81664-1

Reference yield:

: 591-20-8
3-Bromophenol

: 113787-86-3
<3-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy>acetyl-L-(S-p-methoxybenzyl)cysteinyl-D-valine benzhydryl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / sodium hydride (50percent oil dispersion) / dimethylformamide / 2 h / 20 °C

2: 1) BuLi, / 1) THF, -78 deg C, 1h, 2) THF, -78 deg C, 1h

3: 99 percent / hydroxylamine hydrochloride / pyridine; ethanol / 4 h / Heating

4: 85 percent / pyridine / 2 h / Heating

5: 73 percent / NH₃ / diethyl ether / 8 h / -78 °C

6: Ag₂O / diethyl ether / 3 h / in the dark

7: 54 percent / glacial acetic acid, 2M HCl / 3 h / in the dark

8: 95 percent / potassium carbonate / acetone / in the dark

With pyridine; hydrogenchloride; n-butyllithium; hydroxylamine hydrochloride; ammonia; sodium hydride; potassium carbonate; acetic acid; silver(l) oxide; In pyridine; diethyl ether; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)81664-1

Reference yield:

: 42471-59-0
1-bromo-3-(methoxymethoxy)benzene

: 113787-86-3
<3-(3-trifluoromethyl-3H-diazirin-3-yl)phenoxy>acetyl-L-(S-p-methoxybenzyl)cysteinyl-D-valine benzhydryl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1) BuLi, / 1) THF, -78 deg C, 1h, 2) THF, -78 deg C, 1h

2: 99 percent / hydroxylamine hydrochloride / pyridine; ethanol / 4 h / Heating

3: 85 percent / pyridine / 2 h / Heating

4: 73 percent / NH₃ / diethyl ether / 8 h / -78 °C

5: Ag₂O / diethyl ether / 3 h / in the dark

6: 54 percent / glacial acetic acid, 2M HCl / 3 h / in the dark

7: 95 percent / potassium carbonate / acetone / in the dark

With pyridine; hydrogenchloride; n-butyllithium; hydroxylamine hydrochloride; ammonia; potassium carbonate; acetic acid; silver(l) oxide; In pyridine; diethyl ether; ethanol; acetone;
DOI:10.1016/S0040-4020(01)81664-1