(4-chloro-6-methoxy-2-methylsulfanylpyrimidin-5-yl)phenylmethanone

Base Information

• Chemical Name: (4-chloro-6-methoxy-2-methylsulfanylpyrimidin-5-yl)phenylmethanone
• CAS No.: 1393456-84-2
• Molecular Formula: C₁₃H₁₁ClN₂O₂S
• Molecular Weight: 294.762
• Mol file: 1393456-84-2.mol

Synonyms:(4-chloro-6-methoxy-2-methylsulfanylpyrimidin-5-yl)phenylmethanone

Chemical Property of (4-chloro-6-methoxy-2-methylsulfanylpyrimidin-5-yl)phenylmethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (4-chloro-6-methoxy-2-methylsulfanylpyrimidin-5-yl)phenylmethanone

There total 1 articles about (4-chloro-6-methoxy-2-methylsulfanylpyrimidin-5-yl)phenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N-methoxy-N-methylbenzamide (6919-61-5) + 4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine (89466-42-2) → (4-chloro-6-methoxy-2-methylsulfanylpyrimidin-5-yl)phenylmethanone (1393456-84-2)

Guidance literature:

4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1.5h;

N-methoxy-N-methylbenzamide; In tetrahydrofuran; for 0.5h;

DOI:10.3987/COM-12-12463

Reference yield: 70.0%

bromoacetic acid tert-butyl ester (5292-43-3) + (4-chloro-6-methoxy-2-methylsulfanylpyrimidin-5-yl)phenylmethanone (1393456-84-2) → 1,1-dimethylethyl 4-methoxy-2-methylsulfanyl-5-phenylthieno[2,3-d]pyrimidine-6-carboxylate (1393456-89-7)

Guidance literature:

(4-chloro-6-methoxy-2-methylsulfanylpyrimidin-5-yl)phenylmethanone; With sodium sulfide; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

bromoacetic acid tert-butyl ester; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

With sodium hydride; In N,N-dimethyl-formamide; oil; at 0 ℃; for 0.166667h;

DOI:10.3987/COM-12-12463

Reference yield: 56.0%

(4-chloro-6-methoxy-2-methylsulfanylpyrimidin-5-yl)phenylmethanone (1393456-84-2) + cyanomethyl bromide (590-17-0) → 4-methoxy-2-methylsulfanyl-5-phenylthieno[2,3-d]pyrimidine-6-carbonitrile (1393456-88-6)

Guidance literature:

(4-chloro-6-methoxy-2-methylsulfanylpyrimidin-5-yl)phenylmethanone; With sodium sulfide; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

cyanomethyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

With sodium hydride; In N,N-dimethyl-formamide; oil; at 0 ℃; for 0.166667h;

DOI:10.3987/COM-12-12463

upstream raw materials:

N-methoxy-N-methylbenzamide

4-chloro-6-methoxy-2-(methylsulfanyl)pyrimidine

Downstream raw materials:

1,1-dimethylethyl 4-methoxy-2-methylsulfanyl-5-phenylthieno[2,3-d]pyrimidine-6-carboxylate

4-methoxy-2-methylsulfanyl-5-phenylthieno[2,3-d]pyrimidine-6-carbonitrile