1-{3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl}-4-[(benzylamino)methyl]piperidine

Base Information

Chemical Name:1-{3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl}-4-[(benzylamino)methyl]piperidine
CAS No.:177945-83-4
Molecular Formula:C₂₆H₃₂N₆
Molecular Weight:428.58
Hs Code.:

Synonyms:1-{3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl}-4-[(benzylamino)methyl]piperidine

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Chemical Property of 1-{3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl}-4-[(benzylamino)methyl]piperidine

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Technology Process of 1-{3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl}-4-[(benzylamino)methyl]piperidine

There total 6 articles about 1-{3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl}-4-[(benzylamino)methyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 154594-16-8
4-(1,2,4-triazol-4-yl)phenylhydrazine

: 177947-85-2
5-{4-(benzylaminomethyl)piperidin-1-yl}pentanal dimethyl acetal

: 177945-83-4
1-{3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl}-4-[(benzylamino)methyl]piperidine

Guidance literature:: With sulfuric acid; for 20h; Heating;
DOI:10.1021/jm9910021

Reference yield:

: 7144-05-0
4-Aminomethylpiperidine

: 177945-83-4
1-{3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl}-4-[(benzylamino)methyl]piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 5 °C / Heating

2: NaBH₄ / ethanol / 1.25 h

3: 61 percent / K₂CO₃ / dimethylformamide / 3 h / 80 - 90 °C

4: 47 percent / 4 percent aq.H₂SO₄ / 20 h / Heating

With sodium tetrahydroborate; sulfuric acid; potassium carbonate; In ethanol; N,N-dimethyl-formamide; toluene; 1: Condensation / 2: Reduction / 3: Alkylation / 4: Fisher indolization;
DOI:10.1021/jm9910021

Reference yield:

: 100-52-7
benzaldehyde

: 177945-83-4
1-{3-[5-(1,2,4-Triazol-4-yl)-1H-indol-3-yl]propyl}-4-[(benzylamino)methyl]piperidine

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 5 °C / Heating

2: NaBH₄ / ethanol / 1.25 h

3: 61 percent / K₂CO₃ / dimethylformamide / 3 h / 80 - 90 °C

4: 47 percent / 4 percent aq.H₂SO₄ / 20 h / Heating

With sodium tetrahydroborate; sulfuric acid; potassium carbonate; In ethanol; N,N-dimethyl-formamide; toluene; 1: Condensation / 2: Reduction / 3: Alkylation / 4: Fisher indolization;
DOI:10.1021/jm9910021