4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester

Base Information

Chemical Name:4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester
CAS No.:124031-00-1
Molecular Formula:C₁₂H₁₀ClNO₅
Molecular Weight:283.668
Hs Code.:

Synonyms:4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester

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Chemical Property of 4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester

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Technology Process of 4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester

There total 3 articles about 4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 170959-85-0
4-hydroxyfurol<2,3-b>pyridine-2,5-dicarboxylic acid 5-ethyl 2-methyl ester

: 124031-00-1
4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester

Guidance literature:: With trichlorophosphate; In toluene; at 100 ℃; for 1.5h;
DOI:10.1002/jhet.5570320431

Reference yield:

: 611-13-2
2-furoic acid methyl ester

: 124031-00-1
4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / 90percent HNO₃ / acetic anhydride; CH₂Cl₂ / 1.) Ac₂O,CH₂Cl₂, -5 deg C, 2h 2.) Ac₂O,CH₂Cl₂, room temp, 5h

2: 84 percent / H₂ / Pd,C / ethyl acetate / 2 h / 40 °C / 2068.6 Torr

3: 78 percent / ethyl acetate / 3.25 h / 120 °C / 1.) concentrated in vacuo at room temp to pot temp 90 deg C

4: 85 percent / 1.) Ph₂CH₂, heated to 240 deg C

5: 81 percent / POCl₃ / toluene / 1.5 h / 100 °C

With hydrogen; nitric acid; trichlorophosphate; palladium on activated charcoal; In dichloromethane; acetic anhydride; ethyl acetate; toluene;
DOI:10.1002/jhet.5570320431

Reference yield:

: 1874-23-3
methyl 5-nitrofuran-2-carboxylate

: 124031-00-1
4-chlorofuro<2,3-b>pyridine-2,5-dicarboxylicacid 5-ethyl 2-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / H₂ / Pd,C / ethyl acetate / 2 h / 40 °C / 2068.6 Torr

2: 78 percent / ethyl acetate / 3.25 h / 120 °C / 1.) concentrated in vacuo at room temp to pot temp 90 deg C

3: 85 percent / 1.) Ph₂CH₂, heated to 240 deg C

4: 81 percent / POCl₃ / toluene / 1.5 h / 100 °C

With hydrogen; trichlorophosphate; palladium on activated charcoal; In ethyl acetate; toluene;
DOI:10.1002/jhet.5570320431