611-13-2

Usage

Chemical Description

Methyl 2-furoate is an ester with the chemical formula C6H6O3, commonly used as a flavoring agent.

Uses

Used in Chemical Synthesis:
Methyl 2-furoate is utilized as a key intermediate in the synthesis of various organic compounds, including cis-fused 5-oxofuro[2,3-b]furans and sesquiterpene lactones. Its unique chemical structure and reactivity make it a valuable building block for the development of novel pharmaceuticals, fragrances, and other specialty chemicals.
Used in Flavor and Fragrance Industry:
Methyl 2-furoate is used as a flavoring agent for its distinctive sweet, tart, and fruity taste, adding depth and complexity to food and beverage products. Its pleasant odor also makes it suitable for use in perfumery and the creation of fragrances, where it can contribute to a wide range of scent profiles.
Used in Pharmaceutical Industry:
Due to its chemical properties and reactivity, Methyl 2-furoate is employed as a starting material or intermediate in the synthesis of various pharmaceutical compounds. Its ability to participate in a range of chemical reactions allows for the development of new drugs with potential therapeutic applications.

Preparation

From 2-furoic acid in methanol solution in the presence of HCl as catalyst (oxidation or Carmizzaro reaction)

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 37, p. 3225, 1989 DOI: 10.1248/cpb.37.3225

Safety Profile

Poison by intraperitoneal route. A skin irritant and lachrymator. When heated to decomposition it emits acrid smoke and irritating fumes.

InChI:InChI=1/C6H6O3/c1-8-6(7)5-3-2-4-9-5/h2-4H,1H3

Synthetic route

furfural (98-01-1) + methanol (67-56-1) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With oxygen at 120℃; under 3750.38 Torr; for 12h; Temperature; Reagent/catalyst; Autoclave;	99.9%
at 100℃; under 4137.29 - 15514.9 Torr; for 3h; Temperature; Pressure;	98%
With dihydrogen peroxide; Al1.3SiW12O40 at 80 - 250℃; Reagent/catalyst;	96%

2-furanoic acid (88-14-2) + dimethyl dicarbonate (4525-33-1) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
magnesium(II) perchlorate In nitromethane at 40℃; for 16h;	99%
With dmap In tetrahydrofuran for 88h;	97%

methanol (67-56-1) + 2-furanoic acid (88-14-2) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With phosphotungstic acid for 4h; Reflux;	98%
With sulfuric acid for 4h; Reflux;	93%
With potassium carbonate In ethyl acetate for 1.5h; Heating;	92%

methanol (67-56-1) + 2-furancarbonyl chloride (527-69-5) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
at 20℃; for 24h;	97%
for 1h; Heating; Yield given;
With triethylamine at 20℃; for 1h; Inert atmosphere;

(2-furyl)methyl alcohol (98-00-0) + methanol (67-56-1) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With dihydrogen peroxide for 3h; Irradiation;	96%
With PdCoBi/C; oxygen; potassium carbonate at 60℃; under 760.051 Torr; for 14h; Schlenk technique; Green chemistry;	96%
With oxygen at 20℃; for 12h; Irradiation;	93%

furan (110-00-9) + methanol (67-56-1) + tetrachloromethane (56-23-5) → 2-furoic acid methyl ester (611-13-2) + furan-2,5-dicarboxylic acid dimethyl ester (4282-32-0)

Conditions	Yield
With copper(l) iodide at 120℃; for 6h; Inert atmosphere; Autoclave;	A 95% B 5%
With copper(l) iodide at 140℃; for 0.5h; Inert atmosphere; Autoclave;	A 60% B 40%

2-furanoic acid (88-14-2) + methyl iodide (74-88-4) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With IRA 904 In acetonitrile 2.) 25 deg C, 10 h;	94%

2-furanoic acid (88-14-2) + carbonic acid dimethyl ester (616-38-6) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With sulfuric acid at 80 - 85℃; for 7.5h; Neat (no solvent);	92.4%

2-furanoic acid (88-14-2) + malonic acid dimethyl ester (108-59-8) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With potassium bromide In N,N-dimethyl-formamide at 130℃; for 12h; Schlenk technique; chemoselective reaction;	90%

methanol (67-56-1) + 3-(furan-2-carbonyl)oxazolidin-2-one (1394836-09-9) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0) In toluene at 25℃; for 12h; Sealed tube; Inert atmosphere; Green chemistry; chemoselective reaction;	88%

methyl 3-aminofuran-2-carboxylate (956034-04-1) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With isopentyl nitrite In tetrahydrofuran at 120℃; under 5250.53 Torr; for 0.333333h;	88%

methanol (67-56-1) + furan-2-yl(1H-pyrrol-1-yl)methanone → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With [2,2]bipyridinyl; bis(1,5-cyclooctadiene)nickel (0) In toluene at 20℃; for 1h; Sealed tube; chemoselective reaction;	87%

methanol (67-56-1) + furil (492-94-4) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With sodium cyanide; potassium iodide at 15℃; Electrochemical reaction;	86%

methanol (67-56-1) + Furan-2-yl-indol-1-yl-methanone (74117-32-1) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With triethylamine for 2.5h;	83%

N-methoxyfuran-2-carboxamide (42361-45-5) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 85℃; for 1.5h; Electrolysis;	83%

methanol (67-56-1) + prop-2-enyl furan-2-carboxylate (4208-49-5) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
at 400℃; for 0.05h; Temperature; Supercritical conditions; Flow reactor; High pressure;	82%

2-furanoic acid (88-14-2) + dimethyl sulfoxide (67-68-5) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With copper(II) chloride monohydrate; dihydrogen peroxide; oxygen; potassium carbonate; calcium chloride at 80℃; for 15h; Sealed tube; Green chemistry;	81%

furfural (98-01-1) + methanol (67-56-1) → 2-furoic acid methyl ester (611-13-2) + trans-azobenzene (17082-12-1) + trans-azoxybenzene (20972-43-4, 21650-65-7, 495-48-7)

Conditions	Yield
With nitrobenzene; triethylamine; N-methyl-4,5-dimethylthiazolium iodide at 60℃; for 96h; Heating;	A 79% B n/a C n/a

furfural (98-01-1) + potassium methanolate (865-33-8) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With tellurium; bismuth (III) nitrate pentahydrate; 5%-palladium/activated carbon; oxygen In methanol at 60℃; under 760.051 Torr; for 8h;	76%

2-bromofuran (584-12-3) + methanol (67-56-1) + carbon monoxide (201230-82-2) → 2-furanoic acid (88-14-2) + 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 42h; Irradiation;	A 2% B 72%

2-bromofuran (584-12-3) + carbon monoxide (201230-82-2) → 2-furanoic acid (88-14-2) + 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate In tetrahydrofuran at 40℃; under 760 Torr; for 42h; Irradiation;	A 2% B 72%

furan-2-carbonyl fluoride (31174-04-6) + tris(2,4,6-trimethoxyphenyl)phosphine (91608-15-0) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
In toluene at 130℃; for 24h; Schlenk technique; Inert atmosphere;	70%

tert.-butylhydroperoxide (75-91-2) + 2-furanoic acid (88-14-2) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With copper doped mesoporous polymelamine-formaldehyde In water; dimethyl sulfoxide at 100℃; for 16h; Catalytic behavior;	65%
With copper quinolate In water; dimethyl sulfoxide at 120℃; for 24h;	44%
Stage #1: tert.-butylhydroperoxide; 2-furanoic acid In water; dimethyl sulfoxide Stage #2: In water; dimethyl sulfoxide at 100℃; for 20h; Sealed tube;	82 %Chromat.

furan (110-00-9) + methyl chloroformate (79-22-1) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
Stage #1: furan With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; cadmium(II) chloride-N,N,N',N'-tetramethylethylenediamine In tetrahydrofuran; hexane at 0 - 20℃; Inert atmosphere; Stage #2: methyl chloroformate In tetrahydrofuran; hexane at 0 - 20℃; Inert atmosphere; chemoselective reaction;	60%

2-(furan-2-yl)-5,5-dimethyl-[1,3,2]dioxaborinane + di-tert-butyl dicarbonate (24424-99-5) + methyl iodide (74-88-4) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
Stage #1: 2-(furan-2-yl)-5,5-dimethyl-[1,3,2]dioxaborinane; di-tert-butyl dicarbonate With 4,4'-dimethyl-2,2'-bipyridines; lithium methanolate; copper(l) chloride In N,N-dimethyl acetamide at 30℃; for 6h; Inert atmosphere; Schlenk technique; Stage #2: methyl iodide In N,N-dimethyl acetamide at 30℃; for 2h; Schlenk technique;	43%

furfural (98-01-1) + ethanol (64-17-5) → 3-furan-2-yl-propenal (623-30-3) + 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With oxygen; potassium carbonate at 140℃; under 2250.23 Torr; for 4h; Reagent/catalyst;	A 21% B n/a
With oxygen at 140℃; under 2250.23 Torr; for 4h; Reagent/catalyst; Autoclave;	A 61.6 %Chromat. B 37 %Chromat.

(2-furyl)methyl alcohol (98-00-0) + potassium methanolate (865-33-8) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With tellurium; bismuth (III) nitrate pentahydrate; 5%-palladium/activated carbon; oxygen In methanol at 60℃; under 760.051 Torr; for 8h;	19%

furfural (98-01-1) + methanol (67-56-1) → 2-furanoic acid (88-14-2) + 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With dihydrogen peroxide; calcium chloride at 65℃; for 48h;	A n/a B 9%

2-furancarbonyl chloride (527-69-5) → 2-furoic acid methyl ester (611-13-2)

Conditions	Yield
With methanol; magnesium methanolate; Petroleum ether
Multi-step reaction with 2 steps 1: 18-crown-6 ether; potassium fluoride / tetrahydrofuran / 24 h / 40 °C / Schlenk technique; Inert atmosphere 2: toluene / 24 h / 130 °C / Schlenk technique; Inert atmosphere View Scheme

2-furoic acid methyl ester (611-13-2) → 2-furanoic acid (88-14-2)

Conditions	Yield
With potassium carbonate; thiophenol In 1-methyl-pyrrolidin-2-one at 190℃; for 0.166667h; Substitution;	100%
With potassium fluoride; thiophenol In various solvent(s) at 190℃; for 0.166667h;	90%
With potassium fluoride; thiophenol In 1-methyl-pyrrolidin-2-one for 0.166667h; Heating;	90%

2,5-bis(methylsulfonyl)-thiophene-1,1-dioxide (852848-12-5) + 2-furoic acid methyl ester (611-13-2) → methyl 4,7-bis(methylsulfonyl)-3a,7a-dihydro-1-benzofuran-2-carboxylate

Conditions	Yield
In 1,1,2,2-tetrachloroethylene at 100℃;	100%

2-furoic acid methyl ester (611-13-2) + 2-chloro-5-methylsulfonyl-thiophene-1,1-dioxide (357199-99-6) → methyl 7-chloro-4-methylsulfonyl-3a,7a-dihydro-1-benzofuran-2-carboxylate

Conditions	Yield
In 1,1,2,2-tetrachloroethylene at 100℃;	100%

2-furoic acid methyl ester (611-13-2) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-N-methyl-2-furancarboxamide (95091-92-2)

Conditions	Yield
With dimethylaluminum chloride In hexane; dichloromethane for 0.5h; Ambient temperature;	99%
Stage #1: 2-furoic acid methyl ester; N,O-dimethylhydroxylamine*hydrochloride In tetrahydrofuran at -20℃; for 0.0833333h; Inert atmosphere; Stage #2: With isopropylmagnesium chloride In tetrahydrofuran; diethyl ether at -20℃; for 0.416667h; Inert atmosphere;	85%

2-furoic acid methyl ester (611-13-2) → (2-furyl)methyl alcohol (98-00-0)

Conditions	Yield
With ethanol; [bis({2‐[bis(propan‐2‐yl)phosphanyl]ethyl})amine](borohydride)(carbonyl)(hydride)iron(II) at 100℃; for 24h; Inert atmosphere; Sealed tube; Darkness;	99%
With C13H34BFeNOP2; hydrogen In tetrahydrofuran at 100℃; under 22502.3 Torr; for 18h; Autoclave; Inert atmosphere;	95%
With [Ru(2-(methylthio)-N-[(pyridin-2-yl)methyl]ethan-1-amine)(triphenylphosphine)Cl2]; potassium tert-butylate; hydrogen In toluene at 80℃; under 37503.8 Torr; for 10h;	80%

2-furoic acid methyl ester (611-13-2) → methyl 5-formylfuran-2-carboxylate (5904-71-2)

Conditions	Yield
With zinc(II) chloride In dichloromethane at 50℃; for 24h; Temperature; Solvent; Reagent/catalyst;	99%
Multi-step reaction with 2 steps 1: formic acid; aqueous sulfuric acid 2: aqueous nitric acid View Scheme
Multi-step reaction with 2 steps 1: acetic acid; sulfuric acid 2: aqueous nitric acid View Scheme
Multi-step reaction with 2 steps 1: chloroform; iron (III)-chloride; sodium sulfate / Reagens 4: Chlorwasserstoff 2: aqueous nitric acid View Scheme
Multi-step reaction with 2 steps 1: acetic acid; sulfuric acid; paraformaldehyde 2: aqueous nitric acid View Scheme

2-furoic acid methyl ester (611-13-2) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-furancarboxylic acid methyl ester

Conditions	Yield
With (iPrPNP)CoCH2SiMe3 In neat (no solvent) at 23℃; for 0.166667h; Reagent/catalyst; Temperature; Inert atmosphere; Glovebox;	99%
With (iPrPNP)CoCH2SiMe3 In neat (no solvent) at 23℃; for 0.166667h; Reagent/catalyst;	99%

2-furoic acid methyl ester (611-13-2) + benzylamine (100-46-9) → furan-2-carboxylic acid benzylamide (10354-48-0)

Conditions	Yield
With 14C2H2F3O(1-)*6C4H8O*La2Na8(14+) at 80℃; for 6h; Inert atmosphere;	99%
With niobium(V) oxide In neat (no solvent) at 140℃; for 30h; Molecular sieve; Inert atmosphere;	87%

2-furoic acid methyl ester (611-13-2) + tris(methylthio)methane (5418-86-0) → tetrathioorthocarbonic acid tetramethyl ester (6156-25-8) + 1-Furan-2-yl-2,2-bis-methylsulfanyl-ethanone

Conditions	Yield
With n-butyllithium In tetrahydrofuran; hexane 1.) -95 deg C, 2 h, 2.) -78 deg C, 30 min;	A n/a B 97%

2-furoic acid methyl ester (611-13-2) + formaldehyd (50-00-0) → methyl 5-(chloromethyl)-2-furoate (2144-37-8)

Conditions	Yield
With hydrogenchloride; sulfuric acid; zinc(II) chloride In dichloromethane; water at 0 - 20℃;	95%
With hydrogenchloride; zinc(II) chloride In dichloromethane at 35℃; for 2.5h;	67%
With hydrogenchloride; zinc(II) chloride In dichloromethane at 35℃;	66%

2-furoic acid methyl ester (611-13-2) + ethyl bromoacetate (105-36-2) → Ethyl 2-furoate (614-99-3)

Conditions	Yield
Stage #1: ethyl bromoacetate With zinc In tetrahydrofuran at 50 - 55℃; for 0.333333h; Stage #2: 2-furoic acid methyl ester In tetrahydrofuran for 8h; Heating;	95%

2-furoic acid methyl ester (611-13-2) + acetic anhydride (108-24-7) → furan-2,5-dicarboxylic acid (3238-40-2)

Conditions	Yield
Stage #1: 2-furoic acid methyl ester; acetic anhydride With aluminium(III) chloride hexahydrate In dichloromethane at 0 - 20℃; for 4h; Stage #2: With sodium hypochlorite; water; sodium hydroxide at 0℃; for 2h;	95%

2-furoic acid methyl ester (611-13-2) + ethanolamine (141-43-5) → N-(2-hydroxyethyl)amide of furan-2-carboxylic acid (107973-15-9)

Conditions	Yield
	94%
With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine In acetonitrile at 20℃; for 15h; Schlenk technique; Inert atmosphere;	94%

2-furoic acid methyl ester (611-13-2) + acetyl chloride (75-36-5) → furan-2,5-dicarboxylic acid (3238-40-2)

Conditions	Yield
Stage #1: 2-furoic acid methyl ester; acetyl chloride With iron(III) chloride In dichloromethane at 0 - 20℃; for 4h; Stage #2: With sodium hypochlorite; water; sodium hydroxide at 0℃; for 2h; Solvent; Reagent/catalyst;	94%

2-furoic acid methyl ester (611-13-2) + (phenylmethylene)bis(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolane) → 1-(furan-2-yl)-2-phenylethanone (86607-65-0)

Conditions	Yield
With lithium tert-butoxide In tetrahydrofuran at 23℃; for 3h; Glovebox;	94%

2-furoic acid methyl ester (611-13-2) → methyl furan-2-carbodithioate (35972-85-1) + O-methyl furan-2-carbothiono ester (76190-23-3)

Conditions	Yield
With Lawessons reagent In xylene for 10h; Heating;	A n/a B 93%

2-furoic acid methyl ester (611-13-2) + 1-octadecanol (112-92-5) → octadecyl furan-2-carboxylate (82701-01-7)

Conditions	Yield
Stage #1: 2-furoic acid methyl ester; 1-octadecanol In xylene for 0.5h; Heating; Stage #2: With TiO(acac)2 In xylene for 13h; Heating;	93%

2-furoic acid methyl ester (611-13-2) → methyl 5-nitrofuran-2-carboxylate (1874-23-3)

Conditions	Yield
Stage #1: 2-furoic acid methyl ester With nitric acid; acetic anhydride at -5℃; for 2h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at -5 - 20℃; for 2h;	90%
Stage #1: 2-furoic acid methyl ester With nitric acid; acetic anhydride at -5℃; for 2h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at -5 - 20℃; for 15h;	90%
With nitric acid In dichloromethane; acetic anhydride 1.) Ac2O,CH2Cl2, -5 deg C, 2h 2.) Ac2O,CH2Cl2, room temp, 5h;	85%
With nitric acid; acetic anhydride; N-ethyl-N,N-diisopropylamine 1) -5 deg C, 4 h; 2) CH2Cl2, rt, 15 h; Yield given. Multistep reaction;

2-furoic acid methyl ester (611-13-2) + potassium trimethylsilonate (10519-96-7) → potassium furan-2-carboxylate (20842-02-8)

Conditions	Yield
In tetrahydrofuran	90%

2-furoic acid methyl ester (611-13-2) → furan-2-carboxylic acid amide (609-38-1)

Conditions	Yield
With amino(methyl)aluminum chloride In benzene at 50℃; for 12h;	89%

2-furoic acid methyl ester (611-13-2) + L-Phenylalaninol (3182-95-4) → (S)-N-(1-hydroxy-3-phenylpropan-2-yl)furan-2-carboxamide

Conditions	Yield
With N,N'-Mes2imidazol-2-ylidene In tetrahydrofuran at 23℃; for 24h;	89%
With 2,8,9-tris(2-methylpropyl)-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane In tetrahydrofuran at 23 - 25℃; Inert atmosphere;	75%

Upstream product

• 88-14-2 2-furanoic acid 
• 77-78-1 dimethyl sulfate 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 584-12-3 2-bromofuran 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 527-69-5 2-furancarbonyl chloride 
• 1708-41-4 2-(furan-2-yl)-1,3-dioxolane 
• 110-00-9 furan 
• 79-22-1 methyl chloroformate 
• 98-00-0 (2-furyl)methyl alcohol 
• 67-68-5 dimethyl sulfoxide 
• 4208-64-4 1-(2-furyl)ethanol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 62435-72-7 2,5-dimethoxy-2,5-dihydro-furan-2-carboxylic acid methyl ester 
• 5380-40-5 furan-2-carboxylic acid benzyl ester 
• 2144-37-8 methyl 5-(chloromethyl)-2-furoate 
• 36802-00-3 1,1-bis-(2'-methoxyfuroyl-5'-methyleneoxy)methane 
• 70117-25-8 methyl 5-(bromomethyl)-furan-2-carboxylate 
• 91352-41-9 5-tert.-Amyl-brenzschleimsaeure-methylester 
• 38071-66-8 methyl 5-isopropylfuran-2-carboxylate 
• 59907-23-2 methyl 5-(tert-butyl)furan-2-carboxylate 
• 615-06-5 3-furan-2-yl-3-oxo-propionic acid methyl ester 
• 345991-81-3 5-[(chloroacetyl-amino)-methyl]-furan-2-carboxylic acid methyl ester 
• 6312-28-3 2-Furyl-quinaldylketon 
• 615-09-8 ethyl 3-(2-furyl)-3-oxopropanoate 
• 1929-89-1 furan-2-carboxylic acid phenylamide 
• 16650-53-6 6-chloro-1-naphthoic acid 

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Oxidative esterification of furfural over Au-Pd/HAP-T and Au-Ag/HAP-T bimetallic catalysts supported on mesoporous hydroxyapatite nanorods

The conversion of furfural, a lignocellulose biomass, into fuels and value-added fine chemicals has attracted many researchers. In this study, structurally uniform and porous hydroxyapatite nanorods (HAP-T) with the gel composition 1Ca2+:0.66PO

Oxidative esterification of alcohols by a single-side organically decorated Anderson-type chrome-based catalyst

The direct esterification of alcohols with non-noble metal-based catalytic systems faces great challenges. Here, we report a new chrome-based catalyst stabilized by a single pentaerythritol decorated Anderson-type polyoxometalate, [N(C4H9)4]3[CrMo6O18(OH)3C{(OCH2)3CH2OH}], which can realize the efficient transformation from alcohols to esters by H2O2oxidation in good yields and high selectivity without extra organic ligands. A variety of alcohols with different functionalities including some natural products and pharmaceutical intermediates are tolerated in this system. The chrome-based catalyst can be recycled several times and still keep the original configuration and catalytic activity. We also propose a reasonable catalytic mechanism and prove the potential for industrial applications.