2-[(Z)-(6S,7S,8R)-9-Iodo-7-(4-methoxy-benzyloxy)-6,8-dimethyl-non-4-enyloxy]-tetrahydro-pyran

Base Information

Chemical Name:2-[(Z)-(6S,7S,8R)-9-Iodo-7-(4-methoxy-benzyloxy)-6,8-dimethyl-non-4-enyloxy]-tetrahydro-pyran
CAS No.:623926-37-4
Molecular Formula:C₂₄H₃₇IO₄
Molecular Weight:516.46
Hs Code.:

Synonyms:2-[(Z)-(6S,7S,8R)-9-Iodo-7-(4-methoxy-benzyloxy)-6,8-dimethyl-non-4-enyloxy]-tetrahydro-pyran

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Chemical Property of 2-[(Z)-(6S,7S,8R)-9-Iodo-7-(4-methoxy-benzyloxy)-6,8-dimethyl-non-4-enyloxy]-tetrahydro-pyran

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Technology Process of 2-[(Z)-(6S,7S,8R)-9-Iodo-7-(4-methoxy-benzyloxy)-6,8-dimethyl-non-4-enyloxy]-tetrahydro-pyran

There total 8 articles about 2-[(Z)-(6S,7S,8R)-9-Iodo-7-(4-methoxy-benzyloxy)-6,8-dimethyl-non-4-enyloxy]-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 623926-34-1
(Z)-(2S,3S,4S)-3-(4-methoxybenzyloxy)-2,4-dimethyl-9-(tetrahydropyran-2-yloxy)non-5-en-1-ol

: 623926-37-4
2-[(Z)-(6S,7S,8R)-9-Iodo-7-(4-methoxy-benzyloxy)-6,8-dimethyl-non-4-enyloxy]-tetrahydro-pyran

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In diethyl ether; benzene;
DOI:10.1016/S0968-0896(03)00186-X

Reference yield:

: 106296-58-6
(2S,3S,4S)-(1-tert-butyldimethylsilanyloxy)-2,4-dimethylhex-5-en-3-ol

: 623926-37-4
2-[(Z)-(6S,7S,8R)-9-Iodo-7-(4-methoxy-benzyloxy)-6,8-dimethyl-non-4-enyloxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 5 steps

1.1: 89 percent / NaH / tetrahydrofuran; dimethylformamide / 48 h / 20 °C

2.1: ozone; pyridine / CH₂Cl₂; methanol / -78 °C

2.2: dimethyl sulfide / CH₂Cl₂; methanol / -78 - 20 °C

3.1: NaHMDS / tetrahydrofuran / 0.83 h / 20 °C

3.2: 0.55 g / tetrahydrofuran / -78 - 20 °C

4.1: 89 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

5.1: 92 percent / I₂; PPh₃; imidazole / benzene; diethyl ether

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; iodine; sodium hexamethyldisilazane; sodium hydride; ozone; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene; 3.2: Wittig reaction;
DOI:10.1016/S0968-0896(03)00186-X

Reference yield:

: 41049-30-3
2-(4-iodobutoxy)tetrahydropyran

: 623926-37-4
2-[(Z)-(6S,7S,8R)-9-Iodo-7-(4-methoxy-benzyloxy)-6,8-dimethyl-non-4-enyloxy]-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 4 steps

1.1: 51 percent / benzene / 36 h / 80 °C

2.1: NaHMDS / tetrahydrofuran / 0.83 h / 20 °C

2.2: 0.55 g / tetrahydrofuran / -78 - 20 °C

3.1: 89 percent / TBAF / tetrahydrofuran / 1 h / 20 °C

4.1: 92 percent / I₂; PPh₃; imidazole / benzene; diethyl ether

With 1H-imidazole; tetrabutyl ammonium fluoride; iodine; sodium hexamethyldisilazane; triphenylphosphine; In tetrahydrofuran; diethyl ether; benzene; 2.2: Wittig reaction;
DOI:10.1016/S0968-0896(03)00186-X