N-(5-Bromo-pyrazin-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide

Base Information

Chemical Name:N-(5-Bromo-pyrazin-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide
CAS No.:1380645-89-5
Molecular Formula:C₂₀H₁₇BrFN₃O₃S
Molecular Weight:478.342
Hs Code.:

Synonyms:N-(5-Bromo-pyrazin-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-Bromo-pyrazin-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide

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Technology Process of N-(5-Bromo-pyrazin-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide

There total 4 articles about N-(5-Bromo-pyrazin-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 59489-71-3
5-amino-2-bromopyrazine

: 1380646-44-5
3-(4-fluorophenyl)-2-(4-methanesulfonylphenyl)propionic acid

: 1380645-89-5
N-(5-Bromo-pyrazin-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: 90536-66-6
4-(methylsulfonyl)phenylacetic acid

: 1380645-89-5
N-(5-Bromo-pyrazin-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / tert-butyl alcohol / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 20 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 1380646-42-3
tert-butyl 2-(4-(methylsulfonyl)phenyl)acetate

: 1380645-89-5
N-(5-Bromo-pyrazin-2-yl)-3-(4-fluoro-phenyl)-2-(4-methanesulfonyl-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.67 h / 0 - 20 °C / Inert atmosphere

1.2: 2 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 20 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;