2-Amino-1-(2-nitro-phenyl)-ethanol hydrochloride

Base Information

• Chemical Name: 2-Amino-1-(2-nitro-phenyl)-ethanol hydrochloride
• CAS No.: 73685-71-9
• Molecular Formula: C₈H₁₀N₂O₃
• Molecular Weight: 182.179
• DSSTox Substance ID: DTXSID30700162
• Mol file: 73685-71-9.mol

Synonyms:73685-71-9;2-AMINO-1-(2-NITRO-PHENYL)-ETHANOL HYDROCHLORIDE;DTXSID30700162;2-amino-1-(2-nitrophenyl)ethanol HCl;2-amino-1-(2-nitrophenyl)ethanol hydrochloride;2-amino-1-(2-nitrophenyl)ethanol;hydrochloride;2-Amino-1-(2-nitrophenyl)ethan-1-ol--hydrogen chloride (1/1)

Chemical Property of 2-Amino-1-(2-nitro-phenyl)-ethanol hydrochloride

Chemical Property:

• PSA: 92.07000
• LogP: 1.81040
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 218.0458199
• Heavy Atom Count: 14
• Complexity: 181

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(CN)O)[N+](=O)[O-].Cl

Technology Process of 2-Amino-1-(2-nitro-phenyl)-ethanol hydrochloride

There total 5 articles about 2-Amino-1-(2-nitro-phenyl)-ethanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-azido-1-(o-nitrophenyl)ethanol → 1-(o-nitrophenyl)-2-aminoethanol (73685-71-9)

Guidance literature:

With triphenylphosphine; at 0 - 20 ℃;

DOI:10.1002/chem.201103833

Reference yield:

2-acetylnitrobenzene (577-59-3) → 1-(o-nitrophenyl)-2-aminoethanol (73685-71-9)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(I) bromide / chloroform; ethyl acetate / 80 °C

2: sodium azide / acetone / 0 - 20 °C

3: sodium tetrahydroborate / 1,4-dioxane; methanol / 0 - 20 °C

4: triphenylphosphine / 0 - 20 °C

With sodium tetrahydroborate; sodium azide; triphenylphosphine; copper(I) bromide; In 1,4-dioxane; methanol; chloroform; ethyl acetate; acetone;

DOI:10.1002/chem.201103833

Reference yield:

2-bromo-1-(2-nitrophenyl)ethanone (6851-99-6) → 1-(o-nitrophenyl)-2-aminoethanol (73685-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium azide / acetone / 0 - 20 °C

2: sodium tetrahydroborate / 1,4-dioxane; methanol / 0 - 20 °C

3: triphenylphosphine / 0 - 20 °C

With sodium tetrahydroborate; sodium azide; triphenylphosphine; In 1,4-dioxane; methanol; acetone;

DOI:10.1002/chem.201103833

upstream raw materials:

2-acetylnitrobenzene

2-azido-1-(2-nitrophenyl)ethan-1-one

2-bromo-1-(2-nitrophenyl)ethanone

(+/-)-2-(2-nitrophenyl)oxirane