3-{4-[(4-chloroanilino)sulfonyl]phenyl}-N-[3-(dimethylamino)propyl]propanamide

Base Information

Chemical Name:3-{4-[(4-chloroanilino)sulfonyl]phenyl}-N-[3-(dimethylamino)propyl]propanamide
CAS No.:415963-49-4
Molecular Formula:C₂₀H₂₆ClN₃O₃S
Molecular Weight:423.964
Hs Code.:

Synonyms:3-{4-[(4-chloroanilino)sulfonyl]phenyl}-N-[3-(dimethylamino)propyl]propanamide

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Chemical Property of 3-{4-[(4-chloroanilino)sulfonyl]phenyl}-N-[3-(dimethylamino)propyl]propanamide

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Technology Process of 3-{4-[(4-chloroanilino)sulfonyl]phenyl}-N-[3-(dimethylamino)propyl]propanamide

There total 4 articles about 3-{4-[(4-chloroanilino)sulfonyl]phenyl}-N-[3-(dimethylamino)propyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871827-59-7
3-{4-[(4-chloroanilino)sulfonyl]phenyl}propanoic acid

: 109-55-7
1-amino-3-(dimethylamino)propane

: 415963-49-4
3-{4-[(4-chloroanilino)sulfonyl]phenyl}-N-[3-(dimethylamino)propyl]propanamide

Guidance literature:: 3-{4-[(4-chloroanilino)sulfonyl]phenyl}propanoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -25 ℃; for 0.5h;

1-amino-3-(dimethylamino)propane; In tetrahydrofuran; at -25 - 20 ℃;
DOI:10.1021/jm050645f

Reference yield:

: 374537-95-8
methyl 3-[4-(chlorosulfonyl)-phenyl]propanoate

: 415963-49-4
3-{4-[(4-chloroanilino)sulfonyl]phenyl}-N-[3-(dimethylamino)propyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 82.4 percent / pyridine / 0 - 20 °C

2.1: aq. NaOH / dioxane / 20 °C

3.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -25 °C

3.2: tetrahydrofuran / -25 - 20 °C

With 4-methyl-morpholine; pyridine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm050645f

Reference yield:

: 415963-48-3
methyl 3-{4-[(4-chloroanilino)sulfonyl]phenyl}propanoate

: 415963-49-4
3-{4-[(4-chloroanilino)sulfonyl]phenyl}-N-[3-(dimethylamino)propyl]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. NaOH / dioxane / 20 °C

2.1: isobutyl chloroformate; N-methylmorpholine / tetrahydrofuran / 0.5 h / -25 °C

2.2: tetrahydrofuran / -25 - 20 °C

With 4-methyl-morpholine; sodium hydroxide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm050645f