1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(2S,3S)-2-phenyl-3-<(3'R,4'S)-3-azido-4-phenylazetidin-2-on-1-yl>azetidine

Base Information

Chemical Name:1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(2S,3S)-2-phenyl-3-<(3'R,4'S)-3-azido-4-phenylazetidin-2-on-1-yl>azetidine
CAS No.:107079-86-7
Molecular Formula:C₃₁H₃₅N₅O₂
Molecular Weight:509.651
Hs Code.:

Synonyms:1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(2S,3S)-2-phenyl-3-<(3'R,4'S)-3-azido-4-phenylazetidin-2-on-1-yl>azetidine

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Chemical Property of 1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(2S,3S)-2-phenyl-3-<(3'R,4'S)-3-azido-4-phenylazetidin-2-on-1-yl>azetidine

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Technology Process of 1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(2S,3S)-2-phenyl-3-<(3'R,4'S)-3-azido-4-phenylazetidin-2-on-1-yl>azetidine

There total 8 articles about 1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(2S,3S)-2-phenyl-3-<(3'R,4'S)-3-azido-4-phenylazetidin-2-on-1-yl>azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7533-40-6,14438-11-0
(S)-2-amino-4-methylpentan-1-ol

: 107079-86-7
1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(2S,3S)-2-phenyl-3-<(3'R,4'S)-3-azido-4-phenylazetidin-2-on-1-yl>azetidine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) potassium hydride / 1.) THF, RT, 17.5 h; 2.) THF, RT, 3 h

2: 92 percent / sodium sulfate / benzene / Ambient temperature

3: triethylamine / CH₂Cl₂ / -78 deg C to room temperature

4: 88 percent / chlorodihydroalane / diethyl ether / 2 h / Heating

5: sodium sulfate / benzene / Ambient temperature

6: triethylamine / CH₂Cl₂ / -90 deg C to room temperature

With chlorohydroalane; potassium hydride; sodium sulfate; triethylamine; In diethyl ether; dichloromethane; benzene;
DOI:10.1021/ja00240a033

Reference yield:

: 100-39-0
benzyl bromide

: 107079-86-7
1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(2S,3S)-2-phenyl-3-<(3'R,4'S)-3-azido-4-phenylazetidin-2-on-1-yl>azetidine

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) potassium hydride / 1.) THF, RT, 17.5 h; 2.) THF, RT, 3 h

2: 92 percent / sodium sulfate / benzene / Ambient temperature

3: triethylamine / CH₂Cl₂ / -78 deg C to room temperature

4: 88 percent / chlorodihydroalane / diethyl ether / 2 h / Heating

5: sodium sulfate / benzene / Ambient temperature

6: triethylamine / CH₂Cl₂ / -90 deg C to room temperature

With chlorohydroalane; potassium hydride; sodium sulfate; triethylamine; In diethyl ether; dichloromethane; benzene;
DOI:10.1021/ja00240a033

Reference yield:

: 88739-85-9
(S)-4-methyl-1-phenylmethoxy-2-pentylamine

: 107079-86-7
1-<(S)-1-(benzyloxy)-4-methylpent-2-yl>-(2S,3S)-2-phenyl-3-<(3'R,4'S)-3-azido-4-phenylazetidin-2-on-1-yl>azetidine

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / sodium sulfate / benzene / Ambient temperature

2: triethylamine / CH₂Cl₂ / -78 deg C to room temperature

3: 88 percent / chlorodihydroalane / diethyl ether / 2 h / Heating

4: sodium sulfate / benzene / Ambient temperature

5: triethylamine / CH₂Cl₂ / -90 deg C to room temperature

With chlorohydroalane; sodium sulfate; triethylamine; In diethyl ether; dichloromethane; benzene;
DOI:10.1021/ja00240a033