Technology Process of N-[5-(5-chloro-2-methylbenzoxazol-6-yl)(2-pyridyl)](2-chlorophenyl)carboxamide
There total 4 articles about N-[5-(5-chloro-2-methylbenzoxazol-6-yl)(2-pyridyl)](2-chlorophenyl)carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-(5-chloro-2-methylbenzoxazol-6-yl)-2-pyridylamine; o-chlorobenzoyl chloride;
With
N-ethyl-N,N-diisopropylamine;
dmap;
at 20 ℃;
With
water; sodium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: ytterbium(III) triflate / ethanol / 1 h / 90 °C
2.1: potassium phosphate / bis[(dicyclohexyl)(4-dimethylaminophenyl)phosphine]palladium(ll) chloride / 1,4-dioxane; acetonitrile; water / 6 h / 85 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine / dmap / 20 °C
3.2: 1 h / 20 °C
With
potassium phosphate; N-ethyl-N,N-diisopropylamine;
dmap; bis[(dicyclohexyl)(4-dimethylaminophenyl)phosphine]palladium(ll) chloride; ytterbium(III) triflate;
In
1,4-dioxane; ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boron tribromide / dichloromethane / 2 h / 20 °C
2.1: ytterbium(III) triflate / ethanol / 1 h / 90 °C
3.1: potassium phosphate / bis[(dicyclohexyl)(4-dimethylaminophenyl)phosphine]palladium(ll) chloride / 1,4-dioxane; acetonitrile; water / 6 h / 85 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / dmap / 20 °C
4.2: 1 h / 20 °C
With
potassium phosphate; boron tribromide; N-ethyl-N,N-diisopropylamine;
dmap; bis[(dicyclohexyl)(4-dimethylaminophenyl)phosphine]palladium(ll) chloride; ytterbium(III) triflate;
In
1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;