1-[(3-Fluorophenyl)methyl]piperidin-4-amine

Base Information

Chemical Name:1-[(3-Fluorophenyl)methyl]piperidin-4-amine
CAS No.:160358-07-6
Molecular Formula:C₁₂H₁₇FN₂
Molecular Weight:208.279
Hs Code.:
DSSTox Substance ID:DTXSID901260391

Synonyms:1-[(3-fluorophenyl)methyl]piperidin-4-amine;SCHEMBL6944257;DTXSID901260391;HMS1699K08;AKOS000127872;160358-07-6;1-[(3-Fluorophenyl)methyl]-4-piperidinamine;EN300-9120253

Suppliers and Price of 1-[(3-Fluorophenyl)methyl]piperidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-[(3-Fluorophenyl)methyl]piperidin-4-amine

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:208.13757671
Heavy Atom Count:15
Complexity:190

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CCC1N)CC2=CC(=CC=C2)F

Technology Process of 1-[(3-Fluorophenyl)methyl]piperidin-4-amine

There total 11 articles about 1-[(3-Fluorophenyl)methyl]piperidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

: tert-butyl (1-(3-fluorobenzyl)piperidin-4-yl)carbamate

: 160358-07-6
4-amine-1-(3-fluoro)benzylpiperidine

Guidance literature:: With hydrogenchloride; In dichloromethane; ethyl acetate; at 20 ℃; for 2h;

Reference yield: 35.0%

: 779339-10-5
tert-butyl 1-(3-fluorobenzyl)piperidin-4-ylcarbamate

: 160358-07-6
4-amine-1-(3-fluoro)benzylpiperidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1139/cjc-2016-0239

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 160358-07-6
4-amine-1-(3-fluoro)benzylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With triethylamine; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1021/acschemneuro.7b00257