(2S,3S)-1-[(2S,4R)-4-tert-butoxy-2-methoxymethyl-pyrrolidin-1-yl]-3-(3-hydroxypropyl)-2-[E-2-(3-methoxyphenyl)-ethenyl]-4-methyl-4-pentene-1-one

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Chemical Name:(2S,3S)-1-[(2S,4R)-4-tert-butoxy-2-methoxymethyl-pyrrolidin-1-yl]-3-(3-hydroxypropyl)-2-[E-2-(3-methoxyphenyl)-ethenyl]-4-methyl-4-pentene-1-one
CAS No.:1380512-48-0
Molecular Formula:C₂₈H₄₃NO₅
Molecular Weight:473.653
Hs Code.:

Synonyms:(2S,3S)-1-[(2S,4R)-4-tert-butoxy-2-methoxymethyl-pyrrolidin-1-yl]-3-(3-hydroxypropyl)-2-[E-2-(3-methoxyphenyl)-ethenyl]-4-methyl-4-pentene-1-one

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Chemical Property of (2S,3S)-1-[(2S,4R)-4-tert-butoxy-2-methoxymethyl-pyrrolidin-1-yl]-3-(3-hydroxypropyl)-2-[E-2-(3-methoxyphenyl)-ethenyl]-4-methyl-4-pentene-1-one

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Technology Process of (2S,3S)-1-[(2S,4R)-4-tert-butoxy-2-methoxymethyl-pyrrolidin-1-yl]-3-(3-hydroxypropyl)-2-[E-2-(3-methoxyphenyl)-ethenyl]-4-methyl-4-pentene-1-one

There total 2 articles about (2S,3S)-1-[(2S,4R)-4-tert-butoxy-2-methoxymethyl-pyrrolidin-1-yl]-3-(3-hydroxypropyl)-2-[E-2-(3-methoxyphenyl)-ethenyl]-4-methyl-4-pentene-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1380512-22-0
anti-(2S,3S)-1-[(2S,4R)-4-tert-butoxy-2-methoxymethyl-pyrrolidin-1-yl]-3-(3-tert-butyldiphenylsilyloxypropyl)-2-[E-2-(3-methoxyphenyl)-ethenyl]-4-methyl-4-pentene-1-one

: 1380512-48-0
(2S,3S)-1-[(2S,4R)-4-tert-butoxy-2-methoxymethyl-pyrrolidin-1-yl]-3-(3-hydroxypropyl)-2-[E-2-(3-methoxyphenyl)-ethenyl]-4-methyl-4-pentene-1-one

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/ejoc.201200073

Reference yield:

: 1380511-89-6
(2S,4R)-1-[(E)-6-(tert-butyldiphenylsilyloxy)-2-methyl-hex-2-enyl]-4-tert-butoxy-2-(methoxymethyl)pyrrolidine

: 1380512-48-0
(2S,3S)-1-[(2S,4R)-4-tert-butoxy-2-methoxymethyl-pyrrolidin-1-yl]-3-(3-hydroxypropyl)-2-[E-2-(3-methoxyphenyl)-ethenyl]-4-methyl-4-pentene-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylaluminum; sodium carbonate / dichloromethane; toluene / 6 h / 0 °C / Inert atmosphere

1.2: 0.25 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; trimethylaluminum; sodium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; toluene; 1.2: Aza-Claisen rearrangement;
DOI:10.1002/ejoc.201200073