(3S,8S,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-hydroxy-8-methyl-9-methoxy-9-(tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate

Base Information

Chemical Name:(3S,8S,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-hydroxy-8-methyl-9-methoxy-9-(tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate
CAS No.:262279-32-3
Molecular Formula:C₅₇H₆₉N₃O₉Si₂
Molecular Weight:996.361
Hs Code.:

(3S,8S,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-hydroxy-8-methyl-9-methoxy-9-(tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate

Synonyms:(3S,8S,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-hydroxy-8-methyl-9-methoxy-9-(tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate

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Chemical Property of (3S,8S,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-hydroxy-8-methyl-9-methoxy-9-(tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate

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Technology Process of (3S,8S,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-hydroxy-8-methyl-9-methoxy-9-(tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate

There total 12 articles about (3S,8S,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-hydroxy-8-methyl-9-methoxy-9-(tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 262279-26-5
(S)-(E)-tert-butyl 3-(tert-butyldiphenylsilyl)oxy-6-iodo-hex-5-enoate

: 262279-27-6
(5R,6S)-3-methoxy-2-methyl-3-(2-tert-butyldiphenylsiloxymethyl-2,4'-trioxazole-4'-yl)-propanal

: 262279-32-3
(3S,8S,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-hydroxy-8-methyl-9-methoxy-9-(tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate

Guidance literature:: With chromium dichloride; nickel dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/ja994003r

Reference yield:

: 14036-55-6
t-butyl vinylacetate

: 262279-32-3
(3S,8S,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-hydroxy-8-methyl-9-methoxy-9-(tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 28.4 g / m-CPBA / CHCl₃ / 20 °C

2.1: 94 percent / AcOH; water / (R,R)-salen-Co / 12 h / 20 °C

3.1: tetrahydrofuran; diethyl ether / 1.5 h / -78 °C

3.2: imidazole / dimethylformamide / 20 °C

3.3: 100 percent / iodine / tetrahydrofuran / 0.5 h / 0 °C

4.1: 80 percent / NiCl₂; CrCl₂ / tetrahydrofuran; dimethylformamide / 20 °C

With chromium dichloride; water; acetic acid; 3-chloro-benzenecarboperoxoic acid; nickel dichloride; (R,R)-Salen-Co; In tetrahydrofuran; diethyl ether; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ja002377a

Reference yield:

: 108100-50-1,111058-62-9,56936-16-4
(+/-)-tert-butyl 3,4-epoxybutanoate

: 262279-32-3
(3S,8S,9S)-(E)-tert-butyl 3-(tert-butyldiphenylsiloxy)-7-hydroxy-8-methyl-9-methoxy-9-(tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-non-5-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / AcOH; water / (R,R)-salen-Co / 12 h / 20 °C

2.1: tetrahydrofuran; diethyl ether / 1.5 h / -78 °C

2.2: imidazole / dimethylformamide / 20 °C

2.3: 100 percent / iodine / tetrahydrofuran / 0.5 h / 0 °C

3.1: 80 percent / NiCl₂; CrCl₂ / tetrahydrofuran; dimethylformamide / 20 °C

With chromium dichloride; water; acetic acid; nickel dichloride; (R,R)-Salen-Co; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/ja002377a