(5R,6S)-3-methoxy-2-methyl-3-(2-tert-butyldiphenylsiloxymethyl-2,4'-trioxazole-4'-yl)-propanal

Base Information

Chemical Name:(5R,6S)-3-methoxy-2-methyl-3-(2-tert-butyldiphenylsiloxymethyl-2,4'-trioxazole-4'-yl)-propanal
CAS No.:262279-27-6
Molecular Formula:C₃₁H₃₃N₃O₆Si
Molecular Weight:571.705
Hs Code.:

Synonyms:(5R,6S)-3-methoxy-2-methyl-3-(2-tert-butyldiphenylsiloxymethyl-2,4'-trioxazole-4'-yl)-propanal

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Chemical Property of (5R,6S)-3-methoxy-2-methyl-3-(2-tert-butyldiphenylsiloxymethyl-2,4'-trioxazole-4'-yl)-propanal

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Technology Process of (5R,6S)-3-methoxy-2-methyl-3-(2-tert-butyldiphenylsiloxymethyl-2,4'-trioxazole-4'-yl)-propanal

There total 5 articles about (5R,6S)-3-methoxy-2-methyl-3-(2-tert-butyldiphenylsiloxymethyl-2,4'-trioxazole-4'-yl)-propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (5S,6S)-6-[2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazol-4-yl]-3,4-dihydroxy-6-methoxy-5-methyl-hexanoic acid methyl ester

: 262279-27-6
(5R,6S)-3-methoxy-2-methyl-3-(2-tert-butyldiphenylsiloxymethyl-2,4'-trioxazole-4'-yl)-propanal

Guidance literature:: With lead(IV) acetate; potassium carbonate; In diethyl ether; at 0 ℃; for 0.25h;
DOI:10.1021/ja994003r

Reference yield:

: 194232-63-8
2''-(tert-Butyl-diphenyl-silanyloxymethyl)-[2,4';2',4'']teroxazole-4-carbaldehyde

: 262279-27-6
(5R,6S)-3-methoxy-2-methyl-3-(2-tert-butyldiphenylsiloxymethyl-2,4'-trioxazole-4'-yl)-propanal

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / TiCl₄ / CH₂Cl₂ / 24 h / -78 - 20 °C

2: 93 percent / silver(I) oxide / 10 h / Heating

3: OsO₄; trimethylamine N-oxide dihydrate; t-BuOH / tetrahydrofuran; H₂O; toluene / 4 h / 20 °C

4: 773 mg / Pb(OAc)4; K₂CO₃ / diethyl ether / 0.25 h / 0 °C

With lead(IV) acetate; osmium(VIII) oxide; trimethylamine-N-oxide; titanium tetrachloride; potassium carbonate; silver(l) oxide; tert-butyl alcohol; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
DOI:10.1021/ja002377a

Reference yield:

: 262279-31-2
(5S,6S)-(E)-methyl 6-methoxy-5-methyl-6-(2-tert-butyldiphenylsiloxymethyl-2,4'-trisoxazole-4'-yl)-hex-3-enoate

: 262279-27-6
(5R,6S)-3-methoxy-2-methyl-3-(2-tert-butyldiphenylsiloxymethyl-2,4'-trioxazole-4'-yl)-propanal

Guidance literature:: Multi-step reaction with 2 steps

1: OsO₄; trimethylamine N-oxide dihydrate; t-BuOH / tetrahydrofuran; H₂O; toluene / 4 h / 20 °C

2: 773 mg / Pb(OAc)4; K₂CO₃ / diethyl ether / 0.25 h / 0 °C

With lead(IV) acetate; osmium(VIII) oxide; trimethylamine-N-oxide; potassium carbonate; tert-butyl alcohol; In tetrahydrofuran; diethyl ether; water; toluene;
DOI:10.1021/ja002377a