3,3-difluoro-2-phenyl-2,3-dihydrofuran

Base Information

• Chemical Name: 3,3-difluoro-2-phenyl-2,3-dihydrofuran
• CAS No.: 958232-01-4
• Molecular Formula: C₁₀H₈F₂O
• Molecular Weight: 182.17
• Mol file: 958232-01-4.mol

Synonyms:3,3-difluoro-2-phenyl-2,3-dihydrofuran

Chemical Property of 3,3-difluoro-2-phenyl-2,3-dihydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-difluoro-2-phenyl-2,3-dihydrofuran

There total 7 articles about 3,3-difluoro-2-phenyl-2,3-dihydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenyl-1-((tetrahydro-2H-pyran-2-yl)oxy)but-3-yn-2-one → 3,3-difluoro-2-phenyl-2,3-dihydrofuran (958232-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / 24 h / 55 °C / Inert atmosphere

2: pyridinium p-toluenesulfonate / methanol / 18 h / 50 °C / Inert atmosphere

3: (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate / tetrahydrofuran / 1 h / 21 °C / Inert atmosphere; Molecular sieve; Sealed tube

With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; pyridinium p-toluenesulfonate; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; methanol;

DOI:10.1016/j.jfluchem.2018.09.009

Reference yield:

2-((2,2-difluoro-1-phenylbut-3-yn-1-yl)oxy)tetrahydro-2H-pyran → 3,3-difluoro-2-phenyl-2,3-dihydrofuran (958232-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium p-toluenesulfonate / methanol / 18 h / 50 °C / Inert atmosphere

2: (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate / tetrahydrofuran / 1 h / 21 °C / Inert atmosphere; Molecular sieve; Sealed tube

With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol;

DOI:10.1016/j.jfluchem.2018.09.009

Reference yield:

methyl 2-phenyl-2-((tetrahydro-2H-pyran-2-yl)oxy)acetate (33973-12-5) → 3,3-difluoro-2-phenyl-2,3-dihydrofuran (958232-01-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 2.5 h / 0 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.25 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 21 °C / Inert atmosphere

3.1: tetrahydrofuran; diethyl ether / 2.5 h / 0 - 21 °C / Inert atmosphere

4.1: 2-iodoxybenzoic acid / tetrahydrofuran; dimethyl sulfoxide / 18 h / 30 °C / Inert atmosphere

5.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / 24 h / 55 °C / Inert atmosphere

6.1: pyridinium p-toluenesulfonate / methanol / 18 h / 50 °C / Inert atmosphere

7.1: (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate / tetrahydrofuran / 1 h / 21 °C / Inert atmosphere; Molecular sieve; Sealed tube

With lithium aluminium tetrahydride; oxalyl dichloride; (triphenylphosphine)gold(I) chloride; 2-iodoxybenzoic acid; silver trifluoromethanesulfonate; pyridinium p-toluenesulfonate; dimethyl sulfoxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;

DOI:10.1016/j.jfluchem.2018.09.009

upstream raw materials:

methyl 2-phenyl-2-((tetrahydro-2H-pyran-2-yl)oxy)acetate

(RS)-methyl mandelate

2-phenyl-<2-oxy>ethanol

2-phenyl-2-((tetrahydro-2H-pyran-2-yl)oxy)acetaldehyde

Downstream raw materials:

3-fluoro-2-phenylfuran