(3R)-1-azabicyclo[2.2.2]oct-3-yl (2R)-2-phenyl-2-piperidin-1-ylpropanoate

Base Information

Chemical Name:(3R)-1-azabicyclo[2.2.2]oct-3-yl (2R)-2-phenyl-2-piperidin-1-ylpropanoate
CAS No.:1034917-43-5
Molecular Formula:C₂₁H₃₀N₂O₂
Molecular Weight:342.481
Hs Code.:

Synonyms:(3R)-1-azabicyclo[2.2.2]oct-3-yl (2R)-2-phenyl-2-piperidin-1-ylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R)-1-azabicyclo[2.2.2]oct-3-yl (2R)-2-phenyl-2-piperidin-1-ylpropanoate

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Technology Process of (3R)-1-azabicyclo[2.2.2]oct-3-yl (2R)-2-phenyl-2-piperidin-1-ylpropanoate

There total 4 articles about (3R)-1-azabicyclo[2.2.2]oct-3-yl (2R)-2-phenyl-2-piperidin-1-ylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31508-44-8
2-phenylpropionic acid methyl ester

: 1034917-43-5
(3R)-1-azabicyclo[2.2.2]oct-3-yl (2R)-2-phenyl-2-piperidin-1-ylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); Methyl formate / Irradiation; Reflux

2: acetonitrile / 20 °C

3: sodium hydride / toluene; mineral oil / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); Methyl formate; sodium hydride; In toluene; acetonitrile; mineral oil;
DOI:10.1016/j.bmcl.2011.10.002

Reference yield:

: 84892-13-7,148600-13-9
methyl 2-bromo-2-phenylpropanoate

: 1034917-43-5
(3R)-1-azabicyclo[2.2.2]oct-3-yl (2R)-2-phenyl-2-piperidin-1-ylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 20 °C

2: sodium hydride / toluene; mineral oil / Reflux

With sodium hydride; In toluene; acetonitrile; mineral oil;
DOI:10.1016/j.bmcl.2011.10.002