1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE

Base Information

• Chemical Name: 1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE
• CAS No.: 78858-42-1
• Molecular Formula: C₂₆H₅₆NO₆P
• Molecular Weight: 509.707
• Mol file: 78858-42-1.mol

Synonyms:1-O-Hexadecyl-2-O-ethyl-sn-glycero-3-phosphocholine

Chemical Property of 1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE

Chemical Property:

• PSA: 86.86000
• LogP: 7.16740

Purity/Quality:

98%, 99% ^*data from raw suppliers

2-O-ethyl PAF C-16 ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: 2-O-ethyl PAF C-16 is a synthetic PAF analog which contains an ethyl group, attached by an ether linkage, at the sn-2 position. It is a less potent agonist than methylcarbamyl PAF C-16 in the induction of platelet aggregation in both human and rabbit PRP. 2-O-ethyl PAF C-16 causes aggregation of neutrophils in the presence of divalent cations and a desensitization to aggregation in the absence of divalent cations.

Technology Process of 1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE

There total 6 articles about 1-O-HEXADECYL-2-O-ETHYL-SN-GLYCERO-3-PHOSPHORYLCHOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonic acid hexadecyl ester (20779-14-0) → 1-hexadecyl-2-ethyl-sn-glycero-3-phosphocholine (78858-42-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) a) petroleum ether, THF, RT, 30 min, b) 60 deg C, 1 h, 2.) reflux, 36 h

2: 90 percent / HCl gas / CHCl₃; methanol / 0.75 h / Ambient temperature

3: triethylamine / benzene / 2 h / Ambient temperature

4: 0.115 g / acetonitrile / 24 h / 65 °C

With hydrogenchloride; sodium hydride; triethylamine; In methanol; chloroform; acetonitrile; benzene;

DOI:10.1021/jo00256a024

Reference yield:

1-hexadecyl-2-ethyl-sn-glycerol (116257-47-7) → 1-hexadecyl-2-ethyl-sn-glycero-3-phosphocholine (78858-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / benzene / 2 h / Ambient temperature

2: 0.115 g / acetonitrile / 24 h / 65 °C

With triethylamine; In acetonitrile; benzene;

DOI:10.1021/jo00256a024

Reference yield:

2-ethyl-3-(triphenylmethyl)-sn-glycerol (116149-98-5) → 1-hexadecyl-2-ethyl-sn-glycero-3-phosphocholine (78858-42-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) NaH / 1.) a) petroleum ether, THF, RT, 30 min, b) 60 deg C, 1 h, 2.) reflux, 36 h

2: 90 percent / HCl gas / CHCl₃; methanol / 0.75 h / Ambient temperature

3: triethylamine / benzene / 2 h / Ambient temperature

4: 0.115 g / acetonitrile / 24 h / 65 °C

With hydrogenchloride; sodium hydride; triethylamine; In methanol; chloroform; acetonitrile; benzene;

DOI:10.1021/jo00256a024

upstream raw materials:

2-(1-hexadecyl-2-ethyl-sn-glycerol)-2-oxo-1,3,2-dioxaphospholane

trimethylamine

methanesulfonic acid hexadecyl ester

1-hexadecyl-2-ethyl-sn-glycerol