2-(3,4-dichloro-α-hydroxybenzyl)-5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole

Base Information

• Chemical Name: 2-(3,4-dichloro-α-hydroxybenzyl)-5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole
• CAS No.: 198128-04-0
• Molecular Formula: C₂₁H₂₃Cl₂N₃O₅S
• Molecular Weight: 500.403
• Mol file: 198128-04-0.mol

Synonyms:2-(3,4-dichloro-α-hydroxybenzyl)-5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole

Chemical Property of 2-(3,4-dichloro-α-hydroxybenzyl)-5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,4-dichloro-α-hydroxybenzyl)-5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole

There total 3 articles about 2-(3,4-dichloro-α-hydroxybenzyl)-5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5-diiodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (198127-92-3) → 2-(3,4-dichloro-α-hydroxybenzyl)-5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole (198128-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) EtMgBr, 2.) CuCN*2LiCl / 1.) ether, CH₂Cl₂, rt, 30 min, 2.) ether, CH₂Cl₂, THF, rt, 20 h

2: 1.) EtMgBr, 2.) H₂O / 1.) hexane, CH₂Cl₂, rt, 1 h, 2.) hexane, CH₂Cl₂, rt, 15 min

3: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, -78 deg C -> rt, 16 h

With n-butyllithium; ethylmagnesium bromide; water;

DOI:10.1016/S0040-4020(97)00939-3

Reference yield:

5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoyl-4-iodoimidazole (198127-95-6) → 2-(3,4-dichloro-α-hydroxybenzyl)-5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole (198128-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) EtMgBr, 2.) H₂O / 1.) hexane, CH₂Cl₂, rt, 1 h, 2.) hexane, CH₂Cl₂, rt, 15 min

2: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, -78 deg C -> rt, 16 h

With n-butyllithium; ethylmagnesium bromide; water;

DOI:10.1016/S0040-4020(97)00939-3

Reference yield:

3,4-dichlorobenzaldehyde (6287-38-3) + 5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole (198127-99-0) → 2-(3,4-dichloro-α-hydroxybenzyl)-5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole (198128-04-0)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, -78 deg C -> rt, 16 h;

DOI:10.1016/S0040-4020(97)00939-3

upstream raw materials:

3,4-dichlorobenzaldehyde

5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole

4,5-diiodo-N,N-dimethyl-1H-imidazole-1-sulfonamide

5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoyl-4-iodoimidazole