5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoyl-4-iodoimidazole

Base Information

• Chemical Name: 5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoyl-4-iodoimidazole
• CAS No.: 198127-95-6
• Molecular Formula: C₁₄H₁₈IN₃O₄S
• Molecular Weight: 451.285
• Mol file: 198127-95-6.mol

Synonyms:5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoyl-4-iodoimidazole

Chemical Property of 5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoyl-4-iodoimidazole

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoyl-4-iodoimidazole

There total 2 articles about 5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoyl-4-iodoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4,5-diiodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (198127-92-3) → 5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoyl-4-iodoimidazole (198127-95-6)

Guidance literature:

4,5-diiodo-N,N-dimethyl-1H-imidazole-1-sulfonamide; With ethylmagnesium bromide; In tetrahydrofuran; at -20 ℃; for 0.5h;

In tetrahydrofuran; for 0.25h;

electrophile; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/S0040-4039(03)01834-3

Reference yield:

4-bromomethyl-1,2-dimethoxybenzene (21852-32-4) + 4,5-diiodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (198127-92-3) → 5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoyl-4-iodoimidazole (198127-95-6)

Guidance literature:

With ethylmagnesium bromide; Yield given. Multistep reaction; 1.) ether, CH₂Cl₂, rt, 30 min, 2.) ether, CH₂Cl₂, THF, rt, 20 h;

DOI:10.1016/S0040-4020(97)00939-3

Reference yield:

5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoyl-4-iodoimidazole (198127-95-6) → 2-(3,4-dichloro-α-hydroxybenzyl)-4-(3,4-dimethoxybenzyl)imidazole

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) EtMgBr, 2.) H₂O / 1.) hexane, CH₂Cl₂, rt, 1 h, 2.) hexane, CH₂Cl₂, rt, 15 min

2: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, -78 deg C -> rt, 16 h

3: 69 percent / HCl / H₂O; methanol / 28 h / Heating

With hydrogenchloride; n-butyllithium; ethylmagnesium bromide; water; In methanol; water;

DOI:10.1016/S0040-4020(97)00939-3

upstream raw materials:

4-bromomethyl-1,2-dimethoxybenzene

4,5-diiodo-N,N-dimethyl-1H-imidazole-1-sulfonamide

Downstream raw materials:

5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole

2-(3,4-dichloro-α-hydroxybenzyl)-5-(3,4-dimethoxybenzyl)-1-dimethylsulfamoylimidazole