5,17-bis(N'-phenylureido)-26,28-dipropoxycalix[4]arene-25,27-diol

Base Information

• Chemical Name: 5,17-bis(N'-phenylureido)-26,28-dipropoxycalix[4]arene-25,27-diol
• CAS No.: 1314582-92-7
• Molecular Formula: C₄₈H₄₈N₄O₆
• Molecular Weight: 776.932
• Mol file: 1314582-92-7.mol

Synonyms:5,17-bis(N'-phenylureido)-26,28-dipropoxycalix[4]arene-25,27-diol

Chemical Property of 5,17-bis(N'-phenylureido)-26,28-dipropoxycalix[4]arene-25,27-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,17-bis(N'-phenylureido)-26,28-dipropoxycalix[4]arene-25,27-diol

There total 5 articles about 5,17-bis(N'-phenylureido)-26,28-dipropoxycalix[4]arene-25,27-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

5,17-diamino-26,28-dipropoxycalix[4]arene-25,27-diol (1314582-91-6) + phenyl isocyanate (103-71-9) → 5,17-bis(N'-phenylureido)-26,28-dipropoxycalix[4]arene-25,27-diol (1314582-92-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 72h; Inert atmosphere;

DOI:10.1016/j.tet.2011.05.049

Reference yield:

5,17-dinitro-26,28-dipropoxycalix[4]arene-25,27-diol (1314582-89-2) → 5,17-bis(N'-phenylureido)-26,28-dipropoxycalix[4]arene-25,27-diol (1314582-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 22 h / Reflux

2: dichloromethane / 72 h / 20 °C / Inert atmosphere

With hydrazine hydrate; In methanol; dichloromethane;

DOI:10.1016/j.tet.2011.05.049

Reference yield:

25,27-bis[(p-nitrophenyl)sulfonyloxy]-26,28-dipropoxy-calix[4]-arene (1314582-83-6) → 5,17-bis(N'-phenylureido)-26,28-dipropoxycalix[4]arene-25,27-diol (1314582-92-7)

Guidance literature:

Multi-step reaction with 4 steps

1: nitric acid; acetic acid / dichloromethane / 48 h / 20 °C

2: potassium hydroxide / ethanol; dichloromethane / 24 h / 20 °C

3: hydrazine hydrate / methanol / 22 h / Reflux

4: dichloromethane / 72 h / 20 °C / Inert atmosphere

With nitric acid; hydrazine hydrate; acetic acid; potassium hydroxide; In methanol; ethanol; dichloromethane;

DOI:10.1016/j.tet.2011.05.049

upstream raw materials:

5,17-dinitro-26,28-dipropoxycalix[4]arene-25,27-diol

5,17-diamino-26,28-dipropoxycalix[4]arene-25,27-diol

phenyl isocyanate

25,27-bis[(p-nitrophenyl)sulfonyloxy]-26,28-dipropoxy-calix[4]-arene