4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]butanoic acid

Base Information

Chemical Name:4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]butanoic acid
CAS No.:1334606-48-2
Molecular Formula:C₂₆H₂₇N₃O₃
Molecular Weight:429.519
Hs Code.:

Synonyms:4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]butanoic acid

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Chemical Property of 4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]butanoic acid

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Technology Process of 4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]butanoic acid

There total 11 articles about 4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1334607-82-7
ethyl 4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]butanoate

: 1334606-48-2
4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]butanoic acid

Guidance literature:: With water; sodium hydroxide; In isopropyl alcohol; at 20 ℃; for 3h;

Reference yield:

: 1260023-34-4
ethyl 4-(2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanoate

: 1334606-48-2
4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]butanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Inert atmosphere; Sealed; Microwave irradiation

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 130 °C / Inert atmosphere; Sealed; Microwave irradiation

3: sodium hydroxide; water / isopropyl alcohol / 3 h / 20 °C

With potassium phosphate; water; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1258440-84-4
2-[(1-methylethyl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

: 1334607-78-1
ethyl 4-(3-(2-chloropyrimidin-5-yl)-2-ethylphenyl)butanoate

: 1334606-48-2
4-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-5-pyrimidinyl)-2-ethylphenyl]butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 130 °C / Inert atmosphere; Sealed; Microwave irradiation

2: sodium hydroxide; water / isopropyl alcohol / 3 h / 20 °C

With potassium phosphate; water; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; isopropyl alcohol;