(2S,5S,6R,10R,11S)-5-Benzyl-10-heptyl-2-isopropyl-6-methoxymethoxy-4,11-dimethyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione

Base Information

Chemical Name:(2S,5S,6R,10R,11S)-5-Benzyl-10-heptyl-2-isopropyl-6-methoxymethoxy-4,11-dimethyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione
CAS No.:174623-96-2
Molecular Formula:C₃₀H₄₇NO₇
Molecular Weight:533.706
Hs Code.:

Synonyms:(2S,5S,6R,10R,11S)-5-Benzyl-10-heptyl-2-isopropyl-6-methoxymethoxy-4,11-dimethyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione

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Chemical Property of (2S,5S,6R,10R,11S)-5-Benzyl-10-heptyl-2-isopropyl-6-methoxymethoxy-4,11-dimethyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione

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Technology Process of (2S,5S,6R,10R,11S)-5-Benzyl-10-heptyl-2-isopropyl-6-methoxymethoxy-4,11-dimethyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione

There total 16 articles about (2S,5S,6R,10R,11S)-5-Benzyl-10-heptyl-2-isopropyl-6-methoxymethoxy-4,11-dimethyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 174623-95-1
(2S,3R)-3-((3R,4S)-3-Methoxymethoxy-4-methylamino-5-phenyl-pentanoyloxy)-2-methyl-decanoic acid (S)-1-carboxy-2-methyl-propyl ester

: 174623-96-2
(2S,5S,6R,10R,11S)-5-Benzyl-10-heptyl-2-isopropyl-6-methoxymethoxy-4,11-dimethyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 60 ℃; Yield given;

Reference yield:

: 174623-90-6
(3R,4R)-4-[(benzyloxycarbonyl)(methyl) amino]-3-(methoxymethoxy)-5-phenylpentanoic Acid

: 174623-96-2
(2S,5S,6R,10R,11S)-5-Benzyl-10-heptyl-2-isopropyl-6-methoxymethoxy-4,11-dimethyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione

Guidance literature:: Multi-step reaction with 3 steps

1: EDC, DMAP / CH₂Cl₂ / 0 - 20 °C

2: H₂ / Pd(OH)2/C / methanol / 2 h / 760 Torr

3: 2,4,6-trichlorobenzoylchloride, DMAP, EtN(i-Pr)2 / toluene / Ambient temperature

With dmap; 2,4,6-trichlorobenzoyl chloride; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; dichloromethane; toluene;
DOI:10.1016/S0960-894X(99)00243-7

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 174623-96-2
(2S,5S,6R,10R,11S)-5-Benzyl-10-heptyl-2-isopropyl-6-methoxymethoxy-4,11-dimethyl-1,9-dioxa-4-aza-cyclododecane-3,8,12-trione

Guidance literature:: Multi-step reaction with 6 steps

1: DBU / acetonitrile

2: EDC, DMAP / CH₂Cl₂ / 0 - 20 °C

3: HF, pyridine / acetonitrile / 0 °C

4: EDC, DMAP / CH₂Cl₂ / 0 - 20 °C

5: H₂ / Pd(OH)2/C / methanol / 2 h / 760 Torr

6: 2,4,6-trichlorobenzoylchloride, DMAP, EtN(i-Pr)2 / toluene / Ambient temperature

With pyridine; dmap; 2,4,6-trichlorobenzoyl chloride; hydrogen fluoride; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; dichloromethane; toluene; acetonitrile;
DOI:10.1016/S0960-894X(99)00243-7