4-chloro-7-isopropoxyquinoline

Base Information

• Chemical Name: 4-chloro-7-isopropoxyquinoline
• CAS No.: 178984-52-6
• Molecular Formula: C₁₂H₁₂ClNO
• Molecular Weight: 221.686
• Mol file: 178984-52-6.mol

Synonyms:4-chloro-7-isopropoxyquinoline

Chemical Property of 4-chloro-7-isopropoxyquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-7-isopropoxyquinoline

There total 1 articles about 4-chloro-7-isopropoxyquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxy-4(1H)-oxoquinoline (190516-85-9,82121-05-9) → 4-chloro-7-isopropoxyquinoline (178984-52-6)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / Heating

2: hydrogen bromide / Reflux

3: sodium hydride / N,N-dimethyl-formamide / 20 °C

With hydrogen bromide; sodium hydride; trichlorophosphate; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2018.11.048

Reference yield: 73.9%

4-chloro-7-isopropoxyquinoline (178984-52-6) + m-Anisidine (536-90-3,918666-97-4) → 7-isopropoxy-N-(3-methoxyphenyl)quinolin-4-amine

Guidance literature:

With hydrogenchloride; In water; acetone; Reflux;

DOI:10.1016/j.ejmech.2019.05.088

Reference yield: 61.4%

meta-fluoroaniline (372-19-0) + 4-chloro-7-isopropoxyquinoline (178984-52-6)

Guidance literature:

With hydrogenchloride; In water; acetone; Reflux;

DOI:10.1016/j.ejmech.2019.05.088

upstream raw materials:

7-methoxy-4(1H)-oxoquinoline