(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3-carboxy-propyl]-tetrahydro-pyran-2-yl}-hexanoic acid allyl ester

Base Information

• Chemical Name: (3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3-carboxy-propyl]-tetrahydro-pyran-2-yl}-hexanoic acid allyl ester
• CAS No.: 915106-53-5
• Molecular Formula: C₄₆H₇₆O₈Si₃
• Molecular Weight: 841.361
• Mol file: 915106-53-5.mol

Synonyms:(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3-carboxy-propyl]-tetrahydro-pyran-2-yl}-hexanoic acid allyl ester

Chemical Property of (3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3-carboxy-propyl]-tetrahydro-pyran-2-yl}-hexanoic acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3-carboxy-propyl]-tetrahydro-pyran-2-yl}-hexanoic acid allyl ester

There total 1 articles about (3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3-carboxy-propyl]-tetrahydro-pyran-2-yl}-hexanoic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-4-hydroxy-butyl]-tetrahydro-pyran-2-yl}-hexanoic acid allyl ester (915106-62-6) → (3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3-carboxy-propyl]-tetrahydro-pyran-2-yl}-hexanoic acid allyl ester (915106-53-5)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite; phosphate buffer; In acetonitrile; at 50 ℃; for 1h; pH=7;

DOI:10.1021/ol0620904

Reference yield: 72.0%

Octanoic acid (2S,3S,6R)-6-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-2-((E)-1,1-dimethyl-4-oxo-but-2-enyl)-2-hydroxy-4-[1-methoxycarbonyl-meth-(E)-ylidene]-tetrahydro-pyran-3-yl ester + (3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3-carboxy-propyl]-tetrahydro-pyran-2-yl}-hexanoic acid allyl ester (915106-53-5) → C77H128O16Si4

Guidance literature:

(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-3-carboxy-propyl]-tetrahydro-pyran-2-yl}-hexanoic acid allyl ester; With 2,4,6-trichlorobenzoyl chloride; triethylamine; In toluene; at 20 ℃; for 3h;

Octanoic acid (2S,3S,6R)-6-[(R)-3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propyl]-2-((E)-1,1-dimethyl-4-oxo-but-2-enyl)-2-hydroxy-4-[1-methoxycarbonyl-meth-(E)-ylidene]-tetrahydro-pyran-3-yl ester; With dmap; triethylamine; In toluene; at 20 ℃; for 1h;

DOI:10.1021/ol0620904

upstream raw materials:

(3R,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-6-{(2R,6S)-6-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-4-hydroxy-butyl]-tetrahydro-pyran-2-yl}-hexanoic acid allyl ester