1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethyl}-2-vinyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethyl}-2-vinyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester
• CAS No.: 1332699-77-0
• Molecular Formula: C₂₈H₃₀N₂O₅S
• Molecular Weight: 506.623

Synonyms:1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethyl}-2-vinyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester

Chemical Property of 1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethyl}-2-vinyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethyl}-2-vinyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester

There total 13 articles about 1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethyl}-2-vinyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(allyl-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethyl}amino)-2-vinylbut-3-enoic acid methyl ester (1332699-76-9) → 1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethyl}-2-vinyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester (1332699-77-0)

Guidance literature:

With Grubbs catalyst first generation; In dichloromethane; at 20 - 50 ℃; for 21h; under 12929 Torr; Microwave irradiation; Inert atmosphere;

DOI:10.1021/ol201980r

Reference yield:

3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole (1332699-70-3) → 1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethyl}-2-vinyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester (1332699-77-0)

Guidance literature:

Multi-step reaction with 6 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 80 °C / Inert atmosphere

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C / Inert atmosphere

4: pyridine / para-xylene / 3 h / 140 °C / 12929 Torr / Microwave irradiation; Inert atmosphere

5: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 3 h / 80 °C / 12929 Torr / Microwave irradiation; Inert atmosphere

6: Grubbs catalyst first generation / dichloromethane / 21 h / 20 - 50 °C / 12929 Torr / Microwave irradiation; Inert atmosphere

With pyridine; Grubbs catalyst first generation; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; potassium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; para-xylene; ethyl acetate; acetonitrile;

DOI:10.1021/ol201980r

Reference yield:

2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethanol (1332699-71-4) → 1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethyl}-2-vinyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester (1332699-77-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3 h / 80 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C / Inert atmosphere

3: pyridine / para-xylene / 3 h / 140 °C / 12929 Torr / Microwave irradiation; Inert atmosphere

4: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 3 h / 80 °C / 12929 Torr / Microwave irradiation; Inert atmosphere

5: Grubbs catalyst first generation / dichloromethane / 21 h / 20 - 50 °C / 12929 Torr / Microwave irradiation; Inert atmosphere

With pyridine; Grubbs catalyst first generation; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; potassium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; para-xylene; ethyl acetate; acetonitrile;

DOI:10.1021/ol201980r

upstream raw materials:

3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole

2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethanol

4-benzenesulfinyl-2-(2-benzenesulfinylethyl)-2-(benzhydrylideneamino)butyric acid methyl ester

2-amino-4-benzenesulfinyl-2-(2-benzenesulfinylethyl)butyric acid methyl ester

Downstream raw materials:

1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2,3-(tetrahydro-1H-azocino[5,4b]-indol-3-yl)-2,5-dihydro-1H-pyrrole]}-2-carboxylic acid methyl ester

1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2,3,7,8-hexahydro-(1H-azocino[5,4b]-indol-3-yl)-2,5-dihydro-1H-pyrrole]}-2-carboxylic acid methyl ester

1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2,3,7,8-hexahydro-(1H-azocino[5,4b]-indol-3-yl)-2,5-dihydro-1H-pyrrole]}-2-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1332699-77-0 1-{2-[5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indol-3-yl]ethyl}-2-vinyl-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send