3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole

Base Information

Chemical Name:3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole
CAS No.:1332699-70-3
Molecular Formula:C₃₆H₃₉NO₄SSi
Molecular Weight:609.861
Hs Code.:

Synonyms:3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole

Suppliers and Price of 3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole

There total 6 articles about 3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1332699-69-0
2-bromo-3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-1H-indole

: 2,4,6-trivinylcyclotriboroxane*pyridine complex

: 1332699-70-3
3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride; In ethanol; water; toluene; for 20h; Inert atmosphere; Reflux;
DOI:10.1021/ol201980r

Reference yield:

: 1332699-68-9
2-bromo-3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1H-indole

: 1332699-70-3
3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / ethanol; water; toluene / 20 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hexamethyldisilazane; sodium carbonate; lithium chloride; In tetrahydrofuran; ethanol; water; toluene; 2.1: Suzuki coupling;
DOI:10.1021/ol201980r

Reference yield:

: 712-09-4
5-methoxytryptophol

: 1332699-70-3
3-[2-(tert-butyldiphenylsilanyloxy)ethyl]-5-methoxy-1-(toluene-4-sulfonyl)-2-vinyl-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole; dmap / dichloromethane / 0 - 25 °C / Inert atmosphere

2.1: N-Bromosuccinimide / dichloromethane / 0 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

3.2: 3 h / -78 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / ethanol; water; toluene / 20 h / Inert atmosphere; Reflux

With 1H-imidazole; dmap; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hexamethyldisilazane; sodium carbonate; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 4.1: Suzuki coupling;
DOI:10.1021/ol201980r