4-(4-fluoro-phenyl)-5-hydroxymethyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide

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Chemical Name:4-(4-fluoro-phenyl)-5-hydroxymethyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide
CAS No.:855249-01-3
Molecular Formula:C₂₉H₂₉FN₂O₃
Molecular Weight:472.559
Hs Code.:

Synonyms:4-(4-fluoro-phenyl)-5-hydroxymethyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide

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Chemical Property of 4-(4-fluoro-phenyl)-5-hydroxymethyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide

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Technology Process of 4-(4-fluoro-phenyl)-5-hydroxymethyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide

There total 10 articles about 4-(4-fluoro-phenyl)-5-hydroxymethyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 855249-00-2
4-(4-fluoro-phenyl)-5-formyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide

: 855249-01-3
4-(4-fluoro-phenyl)-5-hydroxymethyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide

Guidance literature:: With lithium tri(t-butoxy)aluminum hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1016/j.tet.2007.06.005

Reference yield:

: 855231-02-6
4-(4-fluoro-phenyl)-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid ethyl ester

: 855249-01-3
4-(4-fluoro-phenyl)-5-hydroxymethyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide

Guidance literature:: Multi-step reaction with 5 steps

1: phosphorus oxychloride / 1,2-dichloro-ethane / 18 h / 80 °C

2: 498 g / aq. sodium hydroxide / tetrahydrofuran; methanol / 24 h / 25 °C

3: thionyl chloride / 2 h / 75 °C

4: 11.14 g / triethylamine / CH₂Cl₂ / 2 h / 0 °C

5: 41 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 0.5 h / 0 °C

With sodium hydroxide; thionyl chloride; lithium tri(t-butoxy)aluminum hydride; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; 1: Vilsmeier-Haack reaction;
DOI:10.1016/j.tet.2007.06.005

Reference yield:

: 1027039-32-2
C₂₁H₁₇ClFNO₂

: 855249-01-3
4-(4-fluoro-phenyl)-5-hydroxymethyl-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid 4-methoxybenzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 11.14 g / triethylamine / CH₂Cl₂ / 2 h / 0 °C

2: 41 percent / lithium tri-tert-butoxyaluminohydride / tetrahydrofuran / 0.5 h / 0 °C

With lithium tri(t-butoxy)aluminum hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2007.06.005