(Z)-diethyl-4-diazo-3-methyl-2-(4-nitrobenzyl)pent-2-enedionate

Base Information

• Chemical Name: (Z)-diethyl-4-diazo-3-methyl-2-(4-nitrobenzyl)pent-2-enedionate
• CAS No.: 1399256-04-2
• Molecular Formula: C₁₇H₁₉N₃O₆
• Molecular Weight: 361.354
• Mol file: 1399256-04-2.mol

Synonyms:(Z)-diethyl-4-diazo-3-methyl-2-(4-nitrobenzyl)pent-2-enedionate

Chemical Property of (Z)-diethyl-4-diazo-3-methyl-2-(4-nitrobenzyl)pent-2-enedionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (Z)-diethyl-4-diazo-3-methyl-2-(4-nitrobenzyl)pent-2-enedionate

There total 1 articles about (Z)-diethyl-4-diazo-3-methyl-2-(4-nitrobenzyl)pent-2-enedionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

diazoacetic acid ethyl ester (623-73-4) + (Z)-ethyl 2-(4-nitrobenzyl)-3-trifluoromethanesulfonyloxybut-2-enoate enoltriflate (1399256-23-5) → (Z)-diethyl-4-diazo-3-methyl-2-(4-nitrobenzyl)pent-2-enedionate (1399256-04-2)

Guidance literature:

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/ja307213m

Reference yield: 68.0%

(Z)-diethyl-4-diazo-3-methyl-2-(4-nitrobenzyl)pent-2-enedionate (1399256-04-2) → diethyl 4-(2-methyl-5-nitrobenzyl)-1H-pyrazole-3,5-dicarboxylate (1399256-16-6)

Guidance literature:

With 4-methyl-morpholine; 2,6-di-tert-butyl-4-methyl-phenol; at 60 ℃; Inert atmosphere;

DOI:10.1021/ja307213m

Reference yield: 65.0%

(Z)-diethyl-4-diazo-3-methyl-2-(4-nitrobenzyl)pent-2-enedionate (1399256-04-2) → ethyl 5-ethoxy-3-methyl-4-(4-nitrobenzyl)furan-2-carboxylate

Guidance literature:

With cyclopentadienylruthenium(II) trisacetonitrile hexafluorophosphate; In acetonitrile; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.8b02554

upstream raw materials:

diazoacetic acid ethyl ester

(Z)-ethyl 2-(4-nitrobenzyl)-3-trifluoromethanesulfonyloxybut-2-enoate enoltriflate

Downstream raw materials:

diethyl 4-(2-methyl-5-nitrobenzyl)-1H-pyrazole-3,5-dicarboxylate