Multi-step reaction with 12 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere
1.2: 1 h / -70 °C
2.1: hydrogenchloride / ethyl acetate / 1 h / 0 - 20 °C
3.1: oxalyl dichloride; N,N-dimethyl-formamide / N,N-dimethyl-formamide; toluene / 2 h / 0 - 20 °C / Inert atmosphere
4.1: chloroform / 16 h / 20 °C
5.1: 1-methyl-1H-imidazole / 5 h / 60 °C
6.1: lithium hydroxide; water / ethanol / 20 h / 45 °C
7.1: ammonium chloride; chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 20 °C
8.1: toluene-4-sulfonic acid / 1,2-dichloro-ethane / 2 h / 90 °C
9.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C
10.1: sodium hydroxide; water / methanol / 60 °C
11.1: triethylamine; isobutyl chloroformate / tetrahydrofuran / 0.25 h / 0 °C
11.2: -78 °C
12.1: lithium chloride / N,N-dimethyl-formamide / 1 h / 100 °C
With
1-methyl-1H-imidazole; hydrogenchloride; oxalyl dichloride; water; chloro-N,N,N',N'-bis(tetramethylene)formamidinium hexafluorophosphate; ammonium chloride; caesium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium chloride; sodium hydroxide; lithium hydroxide; lithium hexamethyldisilazane; isobutyl chloroformate;
In
tetrahydrofuran; methanol; ethanol; chloroform; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;