(R)-atomoxetine oxalate

Base Information

• Chemical Name: (R)-atomoxetine oxalate
• CAS No.: 1027094-45-6
• Molecular Formula: C₂H₂O₄*C₁₇H₂₁NO
• Molecular Weight: 345.395
• Mol file: 1027094-45-6.mol

Synonyms:(R)-atomoxetine oxalate

Chemical Property of (R)-atomoxetine oxalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-atomoxetine oxalate

There total 2 articles about (R)-atomoxetine oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxalic acid (144-62-7,97993-78-7) + (R)-tomoxetine (105314-52-1,105314-53-2,63940-51-2,83015-26-3) → (R)-atomoxetine oxalate (1027094-45-6)

Guidance literature:

In isopropyl alcohol; toluene; at 25 - 30 ℃; for 1h;

Reference yield:

tomoxetine oxalic acid salt (107674-34-0) → (R)-atomoxetine oxalate (1027094-45-6)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; for 0.166667h; Product distribution / selectivity; Resolution of racemate;

Reference yield:

(R)-atomoxetine oxalate (1027094-45-6) → atomoxetine hydrochloride (82248-59-7,82857-40-7)

Guidance literature:

(R)-atomoxetine oxalate; With sodium hydroxide; water; In ethyl acetate;

With hydrogenchloride; In ethyl acetate; for 1h;

upstream raw materials:

tomoxetine oxalic acid salt

oxalic acid

(R)-tomoxetine

Downstream raw materials:

(R)-tomoxetine (S)-(+)-mandelate

atomoxetine hydrochloride

Refernces

• 1、 -. "3-ARYLOXY-3-ARYLPROPYLAMINE SYNTHESIS". Page/Page column 12. . Retrieved 2008/06/13.