tert-butyl 9-[(benzyloxy)methyl]-2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,9-tetrahydro-8H-pyrazino[1,2-a]pyrimidine-8-carboxylate

Base Information

• Chemical Name: tert-butyl 9-[(benzyloxy)methyl]-2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,9-tetrahydro-8H-pyrazino[1,2-a]pyrimidine-8-carboxylate
• CAS No.: 911494-28-5
• Molecular Formula: C₂₈H₃₁FN₄O₆
• Molecular Weight: 538.576

Synonyms:tert-butyl 9-[(benzyloxy)methyl]-2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,9-tetrahydro-8H-pyrazino[1,2-a]pyrimidine-8-carboxylate

Chemical Property of tert-butyl 9-[(benzyloxy)methyl]-2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,9-tetrahydro-8H-pyrazino[1,2-a]pyrimidine-8-carboxylate

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Technology Process of tert-butyl 9-[(benzyloxy)methyl]-2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,9-tetrahydro-8H-pyrazino[1,2-a]pyrimidine-8-carboxylate

There total 2 articles about tert-butyl 9-[(benzyloxy)methyl]-2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,9-tetrahydro-8H-pyrazino[1,2-a]pyrimidine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-[(benzyloxy)methyl]-2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidin-8-ium trifluoroacetate (911490-62-5) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 9-[(benzyloxy)methyl]-2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,9-tetrahydro-8H-pyrazino[1,2-a]pyrimidine-8-carboxylate (911494-28-5)

Guidance literature:

In methanol; at 20 ℃;

Reference yield:

C23H23FN4O4 (911490-61-4) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 9-[(benzyloxy)methyl]-2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,9-tetrahydro-8H-pyrazino[1,2-a]pyrimidine-8-carboxylate (911494-28-5)

Guidance literature:

In methanol;

DOI:10.1016/j.tetlet.2008.10.119

Reference yield:

tert-butyl 9-[(benzyloxy)methyl]-2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,9-tetrahydro-8H-pyrazino[1,2-a]pyrimidine-8-carboxylate (911494-28-5) → tert-butyl 2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-9-(hydroxymethyl)-4-oxo-4,6,7,9-tetrahydro-8H-pyrazino[1,2-a]pyrimidine-8-carboxylate (911494-27-4)

Guidance literature:

With 10% Pd/C; hydrogen; In methanol;

DOI:10.1016/j.tetlet.2008.10.119

upstream raw materials:

9-[(benzyloxy)methyl]-2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H-pyrazino[1,2-a]pyrimidin-8-ium trifluoroacetate

di-tert-butyl dicarbonate

C₂₃H₂₃FN₄O₄

Downstream raw materials:

tert-butyl 2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-9-(hydroxymethyl)-4-oxo-4,6,7,9-tetrahydro-8H-pyrazino[1,2-a]pyrimidine-8-carboxylate

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