2-<<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid benzyl ester

Base Information

Chemical Name:2-<<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid benzyl ester
CAS No.:158387-53-2
Molecular Formula:C₃₆H₃₆N₂O₆
Molecular Weight:592.692
Hs Code.:

Synonyms:2-<<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid benzyl ester

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Chemical Property of 2-<<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid benzyl ester

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Technology Process of 2-<<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid benzyl ester

There total 1 articles about 2-<<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 2-<<5-hydroxy-1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid

: 2-<<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid benzyl ester

: 158387-53-2
2-<<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid benzyl ester

Guidance literature:: With caesium carbonate; Yield given. Multistep reaction. Yields of byproduct given; 1.) methanol, reflux, 1 min, 2.) DMF, RT, overnight;
DOI:10.1021/jm00038a011

Reference yield:

: 158387-53-2
2-<<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid benzyl ester

: 2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; under 760 Torr;
DOI:10.1021/jm00038a011

Reference yield:

: 158387-53-2
2-<<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid benzyl ester

: 2-<<5-acetoxy-1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-4-phenylbutanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 130 mg / DMAP, EDCl / CH₂Cl₂ / Ambient temperature

2: 70 mg / H₂ / 5percent Pd-C / ethyl acetate; ethanol / 3 h / 760 Torr

With dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00038a011