Technology Process of (E)-5-(4-fluorophenyl)hex-4-enoic acid
There total 7 articles about (E)-5-(4-fluorophenyl)hex-4-enoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(E)-1-(5-bromopent-2-en-2-yl)-4-fluorobenzene;
With
iodine; magnesium;
In
tetrahydrofuran;
for 2h;
Reflux;
Inert atmosphere;
carbon dioxide;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
Inert atmosphere;
With
hydrogenchloride; water;
In
tetrahydrofuran;
Inert atmosphere;
DOI:10.1021/ol202800k
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen bromide; lithium bromide / water / 2 h / 0 °C / Inert atmosphere
2.1: iodine; magnesium / tetrahydrofuran / 2 h / Reflux; Inert atmosphere
2.2: 0.5 h / 20 °C / Inert atmosphere
2.3: Inert atmosphere
With
hydrogen bromide; iodine; magnesium; lithium bromide;
In
tetrahydrofuran; water;
2.2: Grignard reaction / 2.3: Grignard reaction;
DOI:10.1021/ol202800k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: iodine; magnesium / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
1.2: 1 h / 0 - 20 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: hydrogen bromide; lithium bromide / water / 2 h / 0 °C / Inert atmosphere
3.1: iodine; magnesium / tetrahydrofuran / 2 h / Reflux; Inert atmosphere
3.2: 0.5 h / 20 °C / Inert atmosphere
3.3: Inert atmosphere
With
hydrogen bromide; iodine; magnesium; lithium bromide;
In
tetrahydrofuran; water;
1.2: Grignard reaction / 1.3: Grignard reaction / 3.2: Grignard reaction / 3.3: Grignard reaction;
DOI:10.1021/ol202800k
