4-(3-chlorophenyl)-7-iodo-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Base Information

Chemical Name:4-(3-chlorophenyl)-7-iodo-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile
CAS No.:1616372-06-5
Molecular Formula:C₂₁H₂₀ClIN₄
Molecular Weight:490.774
Hs Code.:

Synonyms:4-(3-chlorophenyl)-7-iodo-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

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Chemical Property of 4-(3-chlorophenyl)-7-iodo-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

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Technology Process of 4-(3-chlorophenyl)-7-iodo-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

There total 6 articles about 4-(3-chlorophenyl)-7-iodo-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616372-00-9
4-(3-chlorophenyl)-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

: 1616372-06-5
4-(3-chlorophenyl)-7-iodo-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: With N-iodo-succinimide; In tetrahydrofuran; at 60 ℃; for 16h; Inert atmosphere;

Reference yield:

: 934-67-8,4331-54-8,13064-83-0
trans-4-methylcyclohexanecarboxylic acid

: 1616372-06-5
4-(3-chlorophenyl)-7-iodo-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 9 h / 0 - 25 °C / Inert atmosphere

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 20 h / 100 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 17 h / 115 °C / Inert atmosphere; Sealed tube

6.1: N-iodo-succinimide / tetrahydrofuran / 16 h / 60 °C / Inert atmosphere

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 3937-49-3
(trans-4-methylcyclohexyl)methanol

: 1616372-06-5
4-(3-chlorophenyl)-7-iodo-5-((trans-4-methylcyclohexyl)methyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 13 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 20 h / 100 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.25 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide / 17 h / 115 °C / Inert atmosphere; Sealed tube

5.1: N-iodo-succinimide / tetrahydrofuran / 16 h / 60 °C / Inert atmosphere

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide; mineral oil;