methyl 1-aza-3-(4-methoxyphenyl)-4-oxobicyclo<4.3.0>-5-nonene-5-carboxylate

Base Information

Chemical Name:methyl 1-aza-3-(4-methoxyphenyl)-4-oxobicyclo<4.3.0>-5-nonene-5-carboxylate
CAS No.:73048-96-1
Molecular Formula:C₁₇H₁₉NO₄
Molecular Weight:301.342
Hs Code.:

Synonyms:methyl 1-aza-3-(4-methoxyphenyl)-4-oxobicyclo<4.3.0>-5-nonene-5-carboxylate

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Chemical Property of methyl 1-aza-3-(4-methoxyphenyl)-4-oxobicyclo<4.3.0>-5-nonene-5-carboxylate

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Technology Process of methyl 1-aza-3-(4-methoxyphenyl)-4-oxobicyclo<4.3.0>-5-nonene-5-carboxylate

There total 8 articles about methyl 1-aza-3-(4-methoxyphenyl)-4-oxobicyclo<4.3.0>-5-nonene-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 73048-95-0
sodium 2-(4-methoxyphenyl)-3-<2-<(methoxycarbonyl)methylene>pyrrolidin-1-yl>propionate

: 79-22-1
methyl chloroformate

: 73048-96-1
methyl 1-aza-3-(4-methoxyphenyl)-4-oxobicyclo<4.3.0>-5-nonene-5-carboxylate

: 73048-94-9
methyl 2-(4-methoxyphenyl)-3-<2-<(methoxycarbonyl)methylene>pyrrolidin-1-yl>propionate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; for 8h; Ambient temperature;
DOI:10.1021/jo01297a049

Reference yield: 11.0%

: 73048-95-0
sodium 2-(4-methoxyphenyl)-3-<2-<(methoxycarbonyl)methylene>pyrrolidin-1-yl>propionate

: 73048-96-1
methyl 1-aza-3-(4-methoxyphenyl)-4-oxobicyclo<4.3.0>-5-nonene-5-carboxylate

: 73048-94-9
methyl 2-(4-methoxyphenyl)-3-<2-<(methoxycarbonyl)methylene>pyrrolidin-1-yl>propionate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; methyl chloroformate; In tetrahydrofuran; for 8h; Ambient temperature;
DOI:10.1021/jo01297a049

Reference yield:

: 68781-79-3
2-(4-Methoxy-phenyl)-3-oxo-succinic acid dimethyl ester

: 73048-96-1
methyl 1-aza-3-(4-methoxyphenyl)-4-oxobicyclo<4.3.0>-5-nonene-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / H₂O / 8.25 h / Ambient temperature

2: 82 percent / NaOH / tetrahydrofuran / 1.) 13h RT, 2.) 3.5h 55 deg C

3: tetrahydrofuran / 16 h / Ambient temperature

4: Ph₃P, NEt₃ / acetonitrile / 0.5 h / Ambient temperature

5: 5.66 g / NaOH / H₂O / 2.5 h / Heating

6: 77 percent / Bu₄NI, methyl chloroformate / tetrahydrofuran / 8 h / Ambient temperature

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; methyl chloroformate; triphenylphosphine; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jo01297a049