methyl 2-[(2,6-dichlorobenzyl)oxy]-3-methylbutanoate

Base Information

Chemical Name:methyl 2-[(2,6-dichlorobenzyl)oxy]-3-methylbutanoate
CAS No.:1558754-12-3
Molecular Formula:C₁₃H₁₆Cl₂O₃
Molecular Weight:291.174
Hs Code.:

Synonyms:methyl 2-[(2,6-dichlorobenzyl)oxy]-3-methylbutanoate

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Chemical Property of methyl 2-[(2,6-dichlorobenzyl)oxy]-3-methylbutanoate

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Technology Process of methyl 2-[(2,6-dichlorobenzyl)oxy]-3-methylbutanoate

There total 3 articles about methyl 2-[(2,6-dichlorobenzyl)oxy]-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 17417-00-4
methyl 2-hydroxy-3-methylbutanoate

: 20443-98-5
2,6-Dichlorobenzyl bromide

: 1558754-12-3
methyl 2-[(2,6-dichlorobenzyl)oxy]-3-methylbutanoate

Guidance literature:: methyl 2-hydroxy-3-methylbutanoate; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.333333h; Inert atmosphere; Schlenk technique;

2,6-Dichlorobenzyl bromide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 5h; Inert atmosphere; Schlenk technique;
DOI:10.1021/ja411772n

Reference yield:

: 4026-18-0,17407-55-5,17407-56-6,600-37-3
2-hydroxy-3-methylbutanoic acid

: 1558754-12-3
methyl 2-[(2,6-dichlorobenzyl)oxy]-3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetyl chloride / 4 h / Inert atmosphere; Schlenk technique; Reflux

2.1: sodium hydride / mineral oil; tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere; Schlenk technique

2.2: 5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With sodium hydride; acetyl chloride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja411772n

Reference yield:

: 516-06-3,25609-85-2,7004-03-7,921-10-8
D,L-valine

: 1558754-12-3
methyl 2-[(2,6-dichlorobenzyl)oxy]-3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid; sodium nitrite / 25 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2.1: acetyl chloride / 4 h / Inert atmosphere; Schlenk technique; Reflux

3.1: sodium hydride / mineral oil; tetrahydrofuran; N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere; Schlenk technique

3.2: 5 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With sulfuric acid; sodium hydride; acetyl chloride; sodium nitrite; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ja411772n